Antimicrobial Effects of Agricultural and Industrial Chemicals on Human Gut Microbiota
November 29, 2025
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Brand Name :
N/A
Synonyms :
isocorynoxeine
Class :
Vasodilating agents/antihypertensive agent
Brand Name :
N/A
Synonyms :
isocorynoxeine
Class :
Vasodilating agents/antihypertensive agent
Dosage Forms and Strengths
In vivo studies suggest that 40 mg/kg administered orally has proven to be effective in rats
Indications: It is claimed to possess anti-spasmodic and sedative effects. It is also known to cause vasodilation, reduce blood pressure, etc
Dosage Forms and Strengths
Data is not available
Refer to adult dosing
Actions and spectrum:
Isocorynoxeine, an alkaloid found in Uncaria, shows various biological activities. It prevents the production of nitric oxide (NO) in rat microglia cells when exposed to LPS (IC50 = 13.7 µM). At 100 µM concentration, isocorynoxeine protects HT22 mouse hippocampal cells against glutamate-induced cytotoxicity.
Frequency not defined
Limited data is available
Black Box Warning
No special black box warnings are available for this drug.
Contraindication/Caution:
Contraindication:
Limited data available
Pregnancy consideration:
Data about the use of isocorynoxeine in pregnancy is not available
Lactation:
Data about the use of isocorynoxeine in lactating mothers is not available.
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Isocorynoxeine is one helpful chemical found in Uncaria plants. These plants are used in traditional Chinese and Japanese medicines. Some people think these traditional remedies help relax the body and muscles. But isocorynoxeine cannot pass from the blood to the brain. Scientists think another chemical made from isocorynoxeine might lower blood pressure. It might also help widen blood vessels and protect brain cells when blood flow is blocked. In addition, when used with doxycycline, isocorynoxeine has been shown to kill hard-to-treat cancer cells.
Pharmacodynamics:
Isocorynoxeine has effects like making you sleepy and stopping muscle tightness. Some think it plays a part in controlling blood pressure, widening blood vessels, and shielding nerves from damage caused by lack of oxygen. Moreover, when used with doxycycline, it may help decrease the survival of cancer cells resistant to multiple drugs.
Pharmacokinetics:
Limited data available
Administration:
Limited data available
Patient information leaflet
Generic Name: isocorynoxeine
Why do we use isocorynoxeine?
Isocorynoxeine is an alkaloid obtained from Uncaria rhychnophylla plant. Its use is suggested for treating high blood pressure. Additionally, it possesses properties that safeguard nerve cells, induce calmness, and prevent seizures. Traditional Chinese medicine employs it for various conditions like eclampsia, dizziness, headaches, colds, seizures, and during pregnancy.
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