kinetin

Action and Spectrum

Actions and Spectrum: 

kinetin is a cytokinin, a class of plant hormones that promote cell division and growth. Although it’s naturally present in plants, it was also found to exist in the DNA of organisms, including humans. Its specific effects in humans are partially elucidated, but it’s known to stimulate differentiation in various cell types, including myoblasts, which are precursor cells to muscle cells.

kinetin’s role in humans goes beyond being a plant hormone; it can affect mRNA splicing, potentially influencing genetic processes. Moreover, it’s used in cosmetic products, although its specific mechanism of action for topical use remains unclear. While naturally occurring in humans, kinetin’s broader spectrum of effects and applications in human biology warrants further research. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Skin irritation 

Enhanced bleeding risk 

Allergic reactions 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication 

None 

Caution 

• Toxicity and Health Concerns: kinetin is generally considered safe when used in appropriate concentrations, but high doses or prolonged exposure could potentially lead to adverse effects. Research is ongoing to determine its long-term safety in various applications. 
• Skin Sensitivity: In skincare products, kinetin is sometimes an anti-aging ingredient due to its potential to promote cell division and repair. However, some individuals may experience skin sensitivity, redness, or irritation when using kinetin products. Patch testing is recommended before widespread use. 
• Allergic Reactions: As with any new substance applied to the skin, there is a risk of allergic reactions. When using kinetin-containing products, it’s essential to be aware of any signs of irritation, redness, itching, or rash. 
• Interaction with Other Ingredients: kinetin-containing products might interact with other skincare ingredients, especially if using multiple products simultaneously. It’s advisable to consult with a dermatologist/skincare professional to ensure that your skincare regimen is well-balanced and compatible. 

Pregnancy / Lactation

Pregnancy consideration:  

US FDA pregnancy category: Not assigned. 

Lactation:   

Excreted into human milk: Not known. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• <b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

kinetin, a plant-derived cytokinin with potential applications in skin care and wound healing, exerts its pharmacological effects by stimulating cell division, delaying cellular senescence, and displaying antioxidant properties. In skin care, kinetin may enhance collagen production, improve skin texture, and reduce inflammation, contributing to potential anti-aging and moisturizing effects.

Though its exact mechanisms remain under investigation, kinetin’s ability to modulate gene expression, promote tissue regeneration, and enhance barrier function makes it an intriguing candidate for therapeutic interventions, necessitating further research to elucidate its mechanisms and optimize its safe and effective use. 

Pharmacodynamics: 

Mechanism of action: The exact mechanism of action of kinetin, particularly in its various applications, still needs to be fully understood and may vary depending on the context. However, some proposed mechanisms are based on research in plant science and its potential effects on human skin.  

Cell Division and Growth: 

kinetin is known to promote cell division and growth in both plants and animals. In plants, it acts as cytokinin, a hormone that regulates cell division and differentiation. In human skin, kinetin’s ability to stimulate cell division may contribute to tissue repair and rejuvenation. 

Delaying Senescence: 

kinetin has been investigated for its potential to delay cellular senescence, which is the process of cell aging and deterioration. By interfering with the natural aging process of cells, kinetin might help maintain cellular function and tissue integrity. 

Anti-Oxidant Properties: 

kinetin has been shown to possess antioxidant properties. It can neutralize harmful free radicals that may cause oxidative damage to cells and tissues. This antioxidant activity may contribute to protecting cells from stress and aging. 

Stimulation of Collagen Production: 

kinetin has been studied for its potential to stimulate collagen production in the skin. Collagen is a protein that generally provides structure and elasticity to the skin. By increasing collagen synthesis, kinetin might improve skin texture and firmness. 

Modulation of Gene Expression: 

It’s suggested that kinetin might influence gene expression in cells. By affecting the expression of the specific genes which is related to growth, repair, and aging, kinetin could have far-reaching effects on cellular processes. 

Anti-Inflammatory Effects: 

Some studies indicate that kinetin might possess anti-inflammatory properties. This could be due to its ability to modulate signaling pathways involved in inflammation, potentially leading to reduced redness, swelling, and discomfort. 

Hydration and Barrier Function: 

kinetin-containing products are often associated with moisturizing effects. kinetin might help improve the skin’s barrier function, reducing water loss and enhancing hydration. 

Wound Healing and Tissue Regeneration: 

kinetin’s promotion of cell division and tissue growth could accelerate wound healing by enhancing the formation of new tissue at site of injury. 

Pharmacokinetics: 

Absorption 

For topical applications, kinetin needs to penetrate the outermost layer of the skin, to exert its effects on underlying skin cells. The extent of absorption can depend on factors like the formulation of the product, the concentration of kinetin, and the skin’s condition. 

Distribution 

If kinetin is absorbed through the skin, it may distribute to various layers of the skin and potentially to underlying tissues. The blood supply might also influence distribution to the skin. 

Metabolism 

Metabolism could involve enzymes that break down kinetin into various metabolites, potentially altering its chemical structure and biological activity. 

Elimination and Excretion 

If formed, kinetin metabolites might be excreted from the body through various routes. In the case of topical applications, the excretion process might involve the shedding of skin cells that have taken up or metabolized kinetin. 

Adminstartion

Administration: 

kinetin is a plant hormone that has also been investigated for its potential benefits in human applications, particularly in skincare, and its potential anti-aging effects. When considering the administration of kinetin in humans, it’s important to follow recommended guidelines and consult with the healthcare professionals to ensure the safe and effective use.  

Topical Application: Kinetin is commonly used in skincare products as a topical treatment. It’s believed to promote cell division and repair, potentially leading to smoother, more youthful-looking skin. When using kinetin-containing skin care products, follow the instructions provided by the manufacturer and consider doing a patch test on a small area of the skin to check for any the adverse reactions or sensitivity. 

Consult a Dermatologist: Before incorporating any new skincare product into your routine, especially one containing kinetin, it’s a good idea to consult a dermatologist. They can assess your skin type and existing skin conditions and recommend products appropriate for your needs. 

Start Slowly: If you’re new to kinetin-containing products, start with a lower concentration and gradually enhance usage if your skin tolerates it well.  

Avoid Sensitive Areas: Be cautious when applying kinetin products around sensitive face areas, such as the eyes and lips. Avoid direct contact with these areas to prevent potential irritation. 

Sun Protection: While kinetin is not known to be photosensitizing, some skincare products might contain other ingredients that increase sun sensitivity. It’s a good practice to use sunscreen during the day, even when using kinetin-containing products, to protect your skin from UV radiation. 

Combination with Other Products: If you’re using other skincare products, consider how kinetin will fit into your overall routine. Certain combinations of products might lead to interactions or reduced efficacy. A dermatologist can guide you in creating a balanced skincare regimen. 

Potential Benefits and Individual Variability: Keep in mind that the potential benefits of kinetin can vary from person to person. Some individuals might notice improvements in their skin’s appearance, while others might not experience significant changes. 

Allergic Reactions: As with any new skincare product, allergic reactions are possible. If you experience redness, itching, swelling, or rash after using a kinetin-containing product, discontinue use and consult a healthcare professional. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: kinetin 

Why do we use kinetin? 

kinetin is a plant growth hormone and cytokinin that has been explored for various applications in science and other fields.  

Medicine and Health: 

• Wound Healing: kinetin’s ability to promote cell division and tissue repair has led to its exploration in wound healing and tissue regeneration. 
• Potential Anti-Inflammatory Effects: Some research suggests that kinetin might have anti-inflammatory properties, which could affect certain health conditions. 

Cryopreservation: 

• kinetin has been used in the cryopreservation of plant tissues. It helps protect cells from damage during freezing, allowing for the long-term storage of plant genetic material. 

Skincare and Cosmetics: 

• Anti-Aging Properties: kinetin has been studied for its potential anti-aging effects on human skin. It may promote cell division and repair, leading to smoother and more youthful-looking skin. 
• Moisturization: kinetin-containing skincare products are often marketed for their moisturizing properties, helping to keep the skin hydrated and supple. 

Plant Growth and Agriculture: 

• kinetin promotes cell division and plant differentiation, enhancing growth and development. kinetin can delay the aging process in plants by preventing or slowing down the process of senescence, which can extend the productive lifespan of crops.