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Brand Name :
Gleostine, CCNU
Synonyms :
chloroethylcyclohexylnitrosourea, cinu, cyclohexyl chloroethyl nitrosourea, lomustina, lomustine, lomustinum
Class :
Antineoplastic agents and Nitrosoureas
Brand Name :
Gleostine, CCNU
Synonyms :
chloroethylcyclohexylnitrosourea, cinu, cyclohexyl chloroethyl nitrosourea, lomustina, lomustine, lomustinum
Class :
Antineoplastic agents and Nitrosoureas
Dosage Forms & Strengths
Capsule
5mg
10mg
40mg
100mg
For untreated patients:
130
mg/m^2
Orally
as a single dose every six weeks
patients with compromised bone marrow function as a dose of 100 mg per m2 orally as a single dose every six weeks
For untreated patients:
130
mg/m^2
Orally
as a single dose every six weeks
patients with compromised bone marrow function as a dose of 100 mg per m2 orally as a single dose every six weeks
Dosage Forms & Strengths
Capsule
5mg
10mg
40mg
100mg
For untreated patients:
130
mg/m^2
orally
as a single dose every six weeks
patients with compromised bone marrow function as a dose of 100 mg per m2 orally as a single dose every six weeks
For untreated patients:
130
mg/m^2
as a single dose every six weeks
patients with compromised bone marrow function as a dose of 100 mg per m2 orally as a single dose every six weeks
It may enhance the immunosuppressive effects when combined with idecabtagene vicleucel
pneumococcal vaccine 13-valent
lomustine diminishes the efficacy of the 13-valent pneumococcal vaccine through pharmacodynamic antagonism
when thiotepa and lomustine combine, the toxicity of both drugs increases by synergism
when both the drugs are combined, the risk or severity of adverse effects increases
when both drugs are combined, there may be an increased risk or severity of adverse effects
risk of severe infection due to immunosuppressive effects
it may increase the level of serum concentration of memantine
may enhance the immunosuppressive effects of each other
when both drugs are combined, there may be an increased risk or severity of adverse effects
Adverse drug reactions:
Frequency defined
>10%
Nausea
Vomiting
1-10%
Myelosuppression
Neurotoxicity
Frequency Not Defined
Ataxia
Alopecia
Elevated LFTs
Hepatic toxicity
Infertility
Optic atrophy
Mucositis
Pulmonary fibrosis
Pulmonary toxicity
Leukemia
Lethargy
Renal toxicity
Stomatitis
Pregnancy warnings:
Breastfeeding warnings:
Pregnancy Categories:
generic name: lomustine
pronounciation: lo·-mus-tine
why do we use lomustine?
lomustine is an anti-cancer agent that belongs to class of alkylating agents, by retarding or cessing the growth of cancerous cells.
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