lonazolac

Action and Spectrum

Actions and Spectrum: 

Actions: 

Lonazolac, like other nonsteroidal anti-inflammatory medicines (NSAIDs), works largely by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. 

Spectrum: 

Lonazolac’s mechanism of action is similar to that of other nonsteroidal anti-inflammatory medicines (NSAIDs) in that it primarily works by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin synthesis. Lonazolac has the following actions: anti-inflammatory, analgesic (pain reliever), and antipyretic (fever reducer). 

Drug Interaction

Adverse Reaction

Frequency not defined 

Allergic skin reactions 

Headache 

Drowsiness 

Dizziness 

Nausea 

Vomiting 

Stomach discomfort 

Black Box Warning

Black Box Warning: 

N/A  

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• Acute gastric ulcer 

Cautions 

• Renal impairment 
• Hepatic impairment 
• Cardiovascular disorders 
• Asthma 
• Hemorrhagic disorders 
• HTN 
• Geriatrics 
• Infections 
• Allergic disorders 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

Lonazolac’s pharmacology is linked to its classification as a nonsteroidal anti-inflammatory medication (NSAID). Lonazolac, like other NSAIDs, works pharmacologically by inhibiting cyclooxygenase (COX) enzymes, resulting in a decrease in prostaglandin synthesis. 

Pharmacodynamics: 

Lonazolac suppresses COX enzyme activity, specifically COX-1 and COX-2. These enzymes are critical in the creation of prostaglandins, which are lipid molecules implicated in the inflammatory response, pain signaling, and body temperature regulation. 

Pharmacokinetics: 

Absorption 

Lonazolac is commonly taken orally in the form of tablets or capsules. It is absorbed from the gastrointestinal system and reaches the bloodstream after oral intake. Absorption rates and extents vary between individuals and may be altered by the presence of food.  

Distribution 

Lonazolac enters the bloodstream and is transported to many tissues throughout the body. NSAIDs, such as lonazolac, have a relatively large volume of distribution, implying that they can permeate tissues, particularly inflamed tissues.  

Metabolism 

Lonazolac may go through metabolic processes in the liver, though specifics concerning its metabolism are lacking. Metabolites can be formed as a result of metabolism.  

Elimination and Excretion 

Lonazolac’s elimination half-life varies between individuals and may be affected by factors like as age, renal function, and liver function. In general, the elimination half-life of NSAIDs is several hours. Lonazolac and its metabolites are mostly eliminated by the kidneys. Factors such as renal function influence the rate of elimination. Some metabolites may be eliminated through the urine. 

Adminstartion

Administration: 

Lonazolac is normally administered by taking the medication by mouth in the form of tablets or capsules. Lonazolac is usually taken with or after a meal to lessen the risk of gastrointestinal adverse effects.

This is also known as “administer with food.” With a full glass of water, swallow the lonazolac tablets or capsules whole. Unless otherwise directed by your healthcare provider, do not crush, chew, or break the pills. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: lonazolac 

Pronounced: Loh-nah-zoh-lak 

Why do we use lonazolac? 

Lonazolac is a nonsteroidal anti-inflammatory medication (NSAID) with anti-inflammatory, analgesic (pain-relieving), and antipyretic (fever-lowering) activities. It was largely given to treat inflammatory and pain-related illnesses.