Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Luzu
Synonyms :
luliconazole
Class :
Antifungals, Topicals
Brand Name :
Luzu
Synonyms :
luliconazole
Class :
Antifungals, Topicals
Dosage forms and strengths
topical cream
Apply 1%
Administer the cream on the affected area and an additional area of one inch daily for seven days
To treat the affected area and the surrounding 1-inch region(s), apply cream once daily for one week
Apply the cream to the affected area and approximately one inch of the adjacent area(s) once a day for two weeks
Dosage forms and strengths
topical cream
Apply 1%
Age 12-18 years: apply a cream to the affected area and an approximate 1-inch radius around it once daily for one week
Age 12-18 years: Apply the cream onto the affected area and approximately one inch of the surrounding area(s) once daily for seven days
Age 2-18 years: Apply the cream to the affected area and the surrounding area(s) measuring approximately 1 inch in diameter once a day for 14 days
Refer adult dosing
Actions and Spectrum
Action:
The drug exerts its action by targeting and inhibiting the enzyme lanosterol 14α-demethylase, which is involved in the synthesis of ergosterol. Ergosterol is a vital component of the fungal cell membrane, necessary for maintaining its structural integrity and normal function. By inhibiting this enzyme, luliconazole prevents the formation of ergosterol, leading to increased permeability and disruption of the fungal cell membrane. This disruption ultimately leads to cell death or growth inhibition of the fungus, thereby treating the fungal infection.
Spectrum:
Tinea pedis (athlete’s foot): The drug can effectively treat fungal infections affecting the skin between the toes and on the feet.
Tinea cruris (jock itch): It is also used for fungal infections in the groin area, characterized by itching, redness, and a rash.
Tinea corporis (ringworm): The drug can treat fungal infections that affect the skin on various body parts, causing circular, itchy rashes.
Cutaneous candidiasis: It is effective against certain yeast infections caused by Candida species, which commonly affect the skin and mucous membranes.
Frequency defined
<1%
Application site reactions
Postmarketing Reports
Contact dermatitis
Cellulitis
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity: The drug should not be used in individuals who have a known hypersensitivity or allergy to luliconazole or any of its components.
Children: The safety and effectiveness of luliconazole in children below the age of 18 years have not been established. It is typically not recommended for pediatric use unless specifically prescribed by a healthcare professional.
Open or damaged skin: The drug should not be applied to open or damaged skin areas. This is because it may be absorbed more readily into the bloodstream and potentially cause systemic side effects.
Eye and mucous membrane contact: The drug is for external use only and should not come into contact with the eyes or mucous membranes.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology: luliconazole is a type of antifungal medication utilized for the treatment of different skin fungal infections, including athlete’s foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis).
Pharmacodynamics: The drug exerts its antifungal effects by inhibiting the enzyme lanosterol 14α-demethylase, which is involved in the conversion of lanosterol to ergosterol. Ergosterol is a vital component of fungal cell membranes, and by inhibiting its synthesis, luliconazole disrupts the integrity and function of the fungal cell membrane, leading to cell death.
Pharmacokinetics:
Absorption
The drug is available as a topical cream or solution for external use. It is absorbed locally into the underlying tissues.
Distribution
The distribution of this drug is primarily limited to the site of application, with minimal systemic absorption. This localized distribution helps to maximize its antifungal activity while minimizing the risk of systemic side effects.
Metabolism
The drug undergoes metabolism in the skin and is primarily metabolized by hepatic cytochrome P450 enzymes, particularly the CYP3A4 isoenzyme.
Excretion and Elimination
The metabolites of luliconazole are eliminated mainly through the feces and urine.
Administration:
Apply a thin layer: Take a sufficient amount of luliconazole cream or lotion and apply it in a thin layer.
Follow the prescribed dosage and duration: The usual recommended dose is to apply the medication once daily for the specified duration, which is typically for 1 to 2 weeks.
Patient information leaflet
Generic Name: luliconazole
Why do we use luliconazole?
Treatment of Tinea Pedis (Athlete’s Foot): The drug is often prescribed to treat tinea pedis, It helps to relieve symptoms such as itching, redness, and scaling.
Treatment of Tinea Cruris (Jock Itch): The drug can also be used to treat tinea cruris, commonly known as jock itch. This fungal infection occurs in the groin area and causes itching, redness, and a rash. luliconazole helps alleviate these symptoms and eliminates the underlying fungal infection.
Treatment of Tinea Corporis (Ringworm): The drug is effective in treating tinea corporis, also known as ringworm. luliconazole helps to clear the infection and reduce the associated symptoms.
Treatment of Tinea Versicolor: The drug can be used to treat tinea versicolor, a superficial fungal infection that causes discolored patches on the skin, typically on the chest, back, and shoulders.
Prevention of Fungal Infections: In some cases, The drug may be prescribed as a preventive measure for individuals at high risk of developing fungal infections.
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