magnesium aspartate

Action and Spectrum

Magnesium aspartate increases the levels of magnesium in the body. Magnesium is necessary mineral which plays an important role in different physiological activities like muscle, neuron function, energy production and synthesis of protein.

Magnesium aspartate is used as a dietary supplement to treat decreased levels of magnesium. The symptoms are muscle weakness, irregular heartbeat. It can treat the diseases like fibromyalgia, restless leg syndrome, chronic fatigue syndrome.

Drug Interaction

Adverse Reaction

Frequency not defined  

Cramps 

Gas formation 

Diarrhea 

Black Box Warning

Magnesium aspartate is a dietary supplement. It is not approved by U.S. FDA. It does not have any black box warning.

Contraindication / Caution

Contraindication:

Do not take magnesium aspartate if you have allergy or sensitive to aspartic acid or magnesium or ff you have poor kidney function or kidney impairment.

Chronic myasthenia

Caution:

Take caution in the pregnant women, patients who have heart disease because of the over dosage of magnesium. It can change the rhythm of heart.

Take caution in patients who are taking antibiotics, diuretics, or drugs for hypertension or osteoporosis because they can interact with magnesium.

Magnesium aspartate must not be used in patients with digestive diseases like inflammatory bowel disease because it can increase the symptoms or cause diarrhea.

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: A 

Lactation: Excretion into human milk is known 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Since magnesium aspartate works by raising the levels of magnesium in the body, its pharmacology is dependent on the pharmacological effects of magnesium.  

magnesium is a necessary mineral that is crucial for numerous physiological functions in the body, such as protein synthesis, energy production, and muscle and neuron function.  

magnesium is necessary for the healthy operation of numerous organs, including the heart, kidneys, and bones. It is involved in approximately 300 enzymatic activities in the body. 

Pharmacodynamics 

The pharmacological effects of magnesium are mostly connected to the pharmacodynamics of magnesium aspartate. 

magnesium is a necessary mineral that is crucial for numerous physiological functions in the body, such as protein synthesis, energy production, and muscle and neuron function. Numerous enzymes involved in the production of proteins, DNA, and RNA, as well as the metabolism of energy, require magnesium as a cofactor.  

Additionally, magnesium controls the release of neurotransmitters and ion channels, both of which are crucial for healthy neuron and muscle function. 

Pharmacokinetics 

Absorption   

When taken orally, magnesium aspartate decomposes into its constituent elements, aspartic acid and magnesium, in the digestive tract. 

Distribution 

The small intestine absorbs magnesium, which the circulation then distributes throughout the body.   

Metabolism 

The liver processes aspartic acid after it is absorbed in the small intestine. 

Elimination and excretion 

The kidneys are the primary organs used to remove magnesium from the body. 

Adminstartion

Magnesium aspartate can be available in the form of pill or tablet. Magnesium aspartate can be taken with food or without food. It is suggested to take it after the meal. It improves the absorption and reduces the risk of any adverse effects of GI.

Patient Information Leaflet

Generic Name: magnesium aspartate

Why do we use magnesium aspartate?

Deficiency of Mg can lead to muscle cramps. Mg is included in relaxation and contraction of muscles. Magnesium aspartate helps to reduce the frequency and severity of muscle cramps by increasing the levels of Mg in the body. Mg helps to relax and control the cardiac cycle in the body. Magnesium aspartate increase the quality of sleep.

The common symptoms are fatigue, muscle pain of diseases like chronic fatigue syndrome and fibromyalgia. Magnesium aspartate may reduce the severity of these symptoms by increasing the levels of magnesium in the body.