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Brand Name :
N/A
Synonyms :
Matrine
Class :
Herbal supplements Oncology
Brand Name :
N/A
Synonyms :
Matrine
Class :
Herbal supplements Oncology
Dosage forms and strength Osteoporosis
It is an alkaloid found in plants from the genus Sophora
It has antitumor activities in vitro and in vivo studies
It is an alkaloid found in plants from the genus Sophora
It has antitumor activities in vitro and in vivo studies
Not determined
GERIATRIC DOSING
Refer to adult dosing
Actions and spectrum:
Matrine induces apoptosis and inhibits the cell proliferation, which results in antitumor activity.
It is an alkaloid found naturally in the plants Radix sophorae tonkinensis and Sophora flavescens.
Adverse reaction
None
Black box warning
None
Contraindication/Caution:
None
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
It has various effects including anticancer effects along with K-opioid and μ-opioid receptor agonism.
Pharmacodynamics:
It inhibits the cell proliferation and induction of apoptosis which is responsible for the drugs antitumor action.
Pharmacokinetics:
Limited data is available.
Administration
None
Patient information leaflet
Generic Name: matrine
Why do we use matrine?
Matrine is investigated for its usefulness in treating cancers such as osteosarcoma, liver cancer, lung cancer, and gall bladder cancer.
In studies it shows a therapeutic effect in Alzheimer’s syndrome, rheumatoid arthritis, osteoporosis, and myocardial ischemia.
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