Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Alkeran [DSC]
(United States) [Available] ,Evomela
(United States) [Available] ,Ivra
(United States) [Available]Synonyms :
Melphalan
Class :
Class: anti cancer drugs (antineoplastic agents), Sub class: nitrogen mustards
Brand Name :
Alkeran [DSC]
(United States) [Available] ,Evomela
(United States) [Available] ,Ivra
(United States) [Available]Synonyms :
Melphalan
Class :
Class: anti cancer drugs (antineoplastic agents), Sub class: nitrogen mustards
Adult dosing:Â
Solution reconstituted intravenous:Â
Tablet, Oral:Â
Â
Palliative treatment:
6
mg
Tablets
Orally 
once a day
2 - 3
weeks
Dose Adjustments
Conditioning treatment: 100 mg/m²/day IV over 30 min 2 days
0.2
mg/kg
Orally
once a day
4 - 5
weeks
; depending on hematologic tolerance repeat for 4-5Weeks
when adenovirus type 7 vaccine live is combined with melphalan the risk and severity of infection can be increased
when bcg vaccine is combined with melphalan the risk or severity of infection can be increased
when cholera vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
influenza virus vaccine quadrivalent
when influenza virus vaccine quadrivalent is combined with melphalan the therapeutic efficacy of the vaccine decreases
when measles vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
measles mumps and rubella vaccine
when measles mumps and rubella vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when rotavirus vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when rubella vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when smallpox vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when typhoid vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when varicella virus vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when yellow fever vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when zoster vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when melphalan is combined with axicabtagene ciloleucel, the risk or severity of adverse effects can be increased
when melphalan is combined with brexucabtagene autoleucel, the risk or severity of adverse effects can be increased
when melphalan is combined with ciltacabtagene autoleucel, the risk or severity of adverse effects can be increased
when melphalan is combined with lisocabtagene maraleucel, the risk or severity of adverse effects can be increased
when natalizumab and melphalan combine, the immunosuppressive effects of both the drugs are enhanced and lead to an increased risk of infection
when melphalan is combined with nivolumab, the risk or severity of adverse effects can be increased
when melphalan is combined with ocrelizumab, the risk or severity of adverse effects can be increased
when used in combination with melphalan the therapeutic efficacy of palifermin can be decreased
when melphalan is combined with pimecrolimus, the risk or severity of adverse effects can be increased
when both drugs combine the toxicity of the drugs increases.
when tacrolimus and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when tisagenlecleucel and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when tofacitinib and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
amphotericin B cholesteryl sulfate
when both drugs combine the toxicity of amphotericin b cholesteryl sulfate increases by melphalan
when both drugs combine the toxicity of amphotericin B deoxycholate increases by melphalan.
when both drugs combine the toxicity of amphotericin B liposomal increases by melphalan.
amphotericin B phospholipid complex
when both drugs combine the toxicity of amphotericin B phospholipid complex increases by melphalan.
when both drugs combine the toxicity of anthrax vaccine adsorbed decreases by melphalan.
when belatacept and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when both drugs combine the toxicity of both drugs increases by synergism
when cyclosporine and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when dengue vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases
when both drugs combine there will be the increased risk of infection.
melphalan decreases the activity of diphtheria & tetanus toxoids by antagonism
when both the drugs combine, echinacea decreases the effect of melphalan.
when fingolimod and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
haemophilus influenzae type b vaccine
when haemophilus influenzae type b vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases by antagonism
hepatitis A vaccine inactivated
when hepatitis a vaccine inactivated is combined with melphalan the therapeutic efficacy of the vaccine decreases by antagonism
when hepatitis a/b vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases by antagonism
when hepatitis b vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases by antagonism
when HIV vaccine is combined with melphalan the therapeutic efficacy of the vaccine decreases by antagonism
human papillomavirus vaccine quadrivalent
when human papillomavirus vaccine, quadrivalent is combined with melphalan the therapeutic efficacy of the vaccine decreases by antagonism
when both the drugs combine there will be increased risk of myelosuppression.
influenza virus vaccine (H N )
melphalan decreases the activity of influenza A (H5N1) vaccine by antagonism
influenza virus vaccine trivalent
melphalan decreases the activity of influenza virus vaccine trivalent by antagonism.
influenza virus vaccine trivalent adjuvanted
melphalan decreases the activity of influenza virus vaccine trivalent, adjuvanted by antagonism.
influenza virus vaccine trivalent recombinant
melphalan decreases the activity of influenza virus vaccine trivalent, recombinant by antagonism.
when isavuconazonium and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when leflunomide and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
meningococcal A C Y and W diphtheria conjugate vaccine
melphalan decreases the activity of meningococcal A C Y and W-135 diphtheria conjugate vaccine by antagonism.
meningococcal A C Y and W polysaccharide vaccine combined
melphalan decreases the activity of meningococcal A C Y and W-135 polysaccharide vaccine combined by antagonism.
melphalan decreases the activity of meningococcal group B vaccine by antagonism.
when ofatumumab sc and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when both drugs combine the toxicity of both drugs increases by synergism
melphalan decreases the activity of pneumococcal vaccine 13-valent by antagonism.
pneumococcal vaccine heptavalent
melphalan decreases the activity of pneumococcal vaccine heptavalent by antagonism.
pneumococcal vaccine polyvalent
melphalan decreases the activity of pneumococcal vaccine polyvalent by antagonism.
poliovirus vaccine inactivated
melphalan decreases the activity of poliovirus vaccine inactivated by antagonism.
melphalan decreases the activity of rabies vaccine inactivated by antagonism.
the effect of melphalan increases by immunosuppressive action.
when siponimod and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
melphalan decreases the activity of sipuleucel-T by antagonism.
when trastuzumab and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when trastuzumab deruxtecan and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when voclosporin and melphalan combine the immunosuppressive effects of both the drugs are enhanced and lead to increased risk of infection
when both drugs combine melphalan decreases the activity of digoxin.
the serum concentration of melphalan is increased with cisplatin when used in combination
When melphalan is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
when melphalan is used in combination with diphtheria & tetanus toxoids, this leads to a reduction in the effects of diphtheria & tetanus toxoids through pharmacodynamic antagonism
may diminish the pharmacodynamic antagonistic effect of each other when combined
measles, mumps, rubella, and varicella vaccine, live 
may diminish the pharmacodynamic antagonistic effect of each other when combined
measles mumps and rubella vaccine, live
may diminish the pharmacodynamic antagonistic effect of each other when combined
may diminish the pharmacodynamic antagonistic effect of each other when combined
smallpox (vaccinia) vaccine, live
may diminish the pharmacodynamic antagonistic effect of each other when combined
when both the drugs are combined, the risk or severity of pulmonary toxicity increases    
when both drugs are combined, there may be an increased risk or severity of adverse effects  
when both drugs are combined, the risk or severity of adverse effects increases 
may enhance the immunosuppressive effects of each other
may increase the risk or severity of toxic effects when combined
when both drugs combine famotidine decreases the activity of melphalan.
when both drugs combine ibuprofen decreases the activity of melphalan.
when both melphalan and vitamin A combine both effect of action increases by synergism.
when both melphalan and vitamin E combine both effect of action increases by synergism.
Adverse drug reactions:Â
Frequency definedÂ
>10%Â
Frequency Not DefinedÂ
Pregnancy and Lactation:Â
Pregnancy:Â
Lactation:Â
Pregnancy Categories:Â Â
Melphalan is an anti-cancer agent that belongs to a class of alkylating agents. It treats myeloma or ovarian cancer by retarding or cessing the growth of cancer cells.
The medicine is taken daily through the mouth in the amount prescribed by the doctor.
Drink ample fluids during the medication period to prevent side effects.
The side effects of melphalan are weight loss, tiredness, trouble sleeping, constipation, diarrhea, vomiting, nausea, loss of appetite, and stomach upset.
Discuss with your pharmacist or physician if you have an allergy to the drug or chlorambucil.
Do not get immunized or vaccinated around the duration of treatment, and avoid meeting people who have recently received the flu vaccine.
As the drug shows transdermal and intrapleural absorption, pregnant women must not inhale the dust of the tablets or take the medication.
There is a possible risk of the drug passing through breast milk. Therefore, lactating women should not breastfeed during the treatment.
Store the medication in a cool and moisture-free place, away from children and pets.
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