meradimate

Action and Spectrum

Actions and spectrum: 

Action: meradimate functions as a chemical absorber of ultraviolet (UV) radiation, specifically in the UVA range. UVA rays penetrate skin more deeply than the UVB rays and are associated with premature skin aging, including wrinkles, fine lines, and pigmentation, as well as potential DNA damage. 

• UV Protection: meradimate primarily absorbs UVA rays by converting the absorbed energy into less harmful forms, such as heat. By doing so, it prevents UVA radiation from reaching the deeper layers of skin, where it can cause damage. 

Spectrum: meradimate’s main UV absorption occurs in the UVA range, which includes wavelengths of around 320 to 400 nanometers. UVA rays are responsible for photoaging and can contribute to long-term skin damage. However, it is important to note that meradimate’s protection might be limited against UVB rays (wavelengths around 280 to 320 nanometers), which are associated with sunburn and are more effectively absorbed by other UV filters. 

• Broad-Spectrum Protection: While meradimate is effective against UVA rays, it is often combined with other UV filters that offer protection across a broader range of wavelengths. This combination of filters aims to provide broad-spectrum protection against both UVA and UVB rays. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Rash 

Itching/swelling 

severe dizziness 

trouble breathing 

Black Box Warning

Black Box Warning:

There were no known black box warnings associated with meradimate (menthyl Anthranilate). 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Skin Sensitivity or Allergies: Some individuals might be sensitive or allergic to certain cosmetic ingredients, including UV filters like meradimate. If you have a known sensitivity or allergy to sunscreen ingredients, you should exercise caution and consider patch testing before using products containing meradimate. 
• Specific Product Formulations: While meradimate itself might not have specific contraindications, the final product formulation in which it is used could have additional ingredients that might be contraindicated for certain individuals.  
• Eye Area: Some skincare products containing meradimate might not be suitable for application around the eye area. Check the product instructions and guidelines to ensure proper use. 
• Children: Some sunscreen products containing meradimate might be formulated specifically for adults and may not be suitable for use on children. Always follow the age recommendations provided on the product label.

Caution: 

• skin Sensitivity: Some individuals might have sensitivities or allergies to cosmetic ingredients, including UV filters like meradimate. It is a good practice to perform a patch test on a small area of skin before applying products containing meradimate to a larger area, especially if you have a history of skin reactions or allergies. 
• Eye Area: Be cautious when applying products containing meradimate around the eye area. Sunscreen formulations can sometimes cause irritation if they come into contact with the eyes.  
• Reapplication: Like other sunscreen products, products containing meradimate should be reapplied as directed to maintain effective sun protection. Sweating, swimming, and toweling off can remove sunscreen, so reapply regularly, especially if you are outdoors for an extended period. 
• Children: If using products containing meradimate on children, choose formulations specifically designed for kids and follow recommendations on the product label. Keep in mind that children’s skin can be more sensitive, and it is important to protect them from excessive sun exposure. 

Comorbidities: 

• Skin Sensitivities and Allergies: Individuals with a history of skin sensitivities, allergies, or dermatological conditions might be more prone to reactions when using skincare products. While allergic reactions to meradimate are rare, it is still possible for some individuals to develop skin irritation or sensitivities. 
• Skin Conditions: Individuals with pre-existing skin conditions such as eczema, psoriasis, or rosacea should be cautious when using new skincare products, including those containing meradimate. It is advisable to consult a dermatologist before introducing new products to your skincare routine. 
• Sun-Related Conditions: Individuals with sun-related conditions like polymorphous light eruption (PMLE) or photosensitivity disorders might need to take extra precautions when using sunscreens. While meradimate helps protect against UV radiation, certain conditions may require specific formulations or alternative sun protection methods. 
• Immune Disorders: Individuals with compromised immune systems might have heightened sensitivities to various substances. It is a good practice to consult a healthcare professional before using new skincare products, especially if you have a medical condition affecting your immune system. 

Pregnancy / Lactation

Pregnancy consideration: pregnancy category: not assigned 

Lactation: excreted into breast milk: unknown  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

meradimate, also known as menthyl Anthranilate, is an organic compound commonly used in sunscreens and other skincare products as a chemical UV filter. Its pharmacology involves its mechanism of action, absorption, and role in protecting the skin from the harmful effects of ultraviolet (UV) radiation.

meradimate works as a chemical absorber of UV radiation, specifically in the UVA range. When applied to the skin, it absorbs UVA rays from the sun, preventing them from penetrating deeper layers of the skin. By absorbing UVA radiation, meradimate helps reduce the risk of UV-induced skin damage, including premature aging and potential DNA damage.  

Pharmacodynamics: 

The pharmacodynamics of meradimate involve its ability to absorb and dissipate UV radiation. When applied to the skin, meradimate absorbs UVA rays from the sun, which are responsible for causing skin damage, including premature aging and potential DNA damage. By absorbing UVA radiation, meradimate prevents these rays from penetrating deeper layers of the skin, helping to reduce the risk of skin damage. 

• UV Absorption: meradimate undergoes a photochemical reaction when exposed to UVA rays. This reaction allows it to absorb the energy from UVA radiation and convert it into heat. As a result, the absorbed UVA energy is dissipated harmlessly as heat, preventing it from causing cellular damage in the skin. 
• Synergy with Other Filters: In sunscreen formulations, meradimate is often used in combination with other UV filters that provide protection against a broader range of UV wavelengths. The combination of different UV filters helps achieve broad-spectrum protection, offering defense against both UVA and UVB radiation. 
• Photo-Stability: One aspect of pharmacodynamics for UV filters like meradimate is their ability to maintain stability under UV exposure. This ensures that the filter remains effective and continues to absorb and dissipate UV radiation over time.

Pharmacokinetics: 

Absorption 

meradimate is applied topically to the skin in the form of sunscreens and skincare products. It is designed to absorb and dissipate UV radiation from the sun, primarily in the UVA range. While it primarily acts on the skin’s surface, some absorption into the upper layers of the skin (epidermis) might occur. 

Distribution 

After topical application, meradimate remains primarily in the area where it is applied on the skin’s surface. It is not expected to be significantly distributed throughout the body or into deeper tissues. 

Metabolism 

meradimate is not typically metabolized within the body. Its primary function is to absorb and dissipate UV radiation on the skin’s surface, rather than undergoing metabolic processes. 

Elimination and excretion 

Since meradimate is not absorbed significantly into the bloodstream, it is not excreted through the typical routes of renal or hepatic excretion. Instead, any residual meradimate on the skin’s surface may be removed through processes such as sweating or washing. 

Adminstartion

Administration: 

• Application: meradimate is applied topically to the skin. It is typically found in sunscreen products, moisturizers, and other skincare formulations that offer UV protection. 
• Usage Instructions: Follow the usage instructions provided on the product label. Apply the product evenly and thoroughly to the areas of skin that are exposed to the sun. 
• Amount: Use the recommended amount of product as specified on the label. Applying too little sunscreen can reduce its effectiveness. 
• Timing: Apply the product before sun exposure, ideally about 15 to 30 minutes before going outdoors. This allows the sunscreen to be absorbed into the skin and provide effective protection. 
• Reapplication: Reapply the sunscreen regularly, especially after swimming, sweating, or towel drying. Even if a product claims to be water-resistant, reapplication is still necessary after certain activities. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: meradimate 

Pronounced: (mer-uh-dih-mat)  

Why do we use meradimate? 

• Sun Protection: meradimate is used in sunscreens to provide protection against UV radiation, specifically in the UVA range. It helps to absorb and dissipate UVA rays from the sun, which are associated with skin aging, wrinkles, and other forms of skin damage. 
• UV-Induced Skin Aging: Exposure to UV radiation can lead to premature skin aging, including the development of wrinkles, fine lines, and age spots. meradimate helps reduce the impact of UV-induced aging by absorbing and mitigating UVA radiation. 
• Photodamage Prevention: Regular use of products containing meradimate can help prevent photodamage, which includes sunburn, redness, and other immediate skin reactions caused by UV exposure. 
• Broad-Spectrum Protection: While meradimate is primarily effective against UVA radiation, it is often used in combination with other UV filters to achieve broad-spectrum protection, including protection against UVB rays, which are responsible for sunburn.