metocurine

Action and Spectrum

Actions and Spectrum 

metocurine belongs to a class of drugs known as non-depolarizing neuromuscular blockers or competitive nicotinic antagonists. It competes with acetylcholine, the neurotransmitter responsible for transmitting nerve signals from motor neurons to muscle cells, for binding to nicotinic acetylcholine receptors on the muscle cell membrane.

Drug Interaction

Adverse Reaction

Frequency not defined  

None 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• metocurine should not be used in individuals who have a known hypersensitivity or allergy to the drug or any of its components. 

Caution: 

• Caution should be exercised when using metocurine in patients with cardiovascular conditions such as cardiac insufficiency and congestive heart failure. 
• Care should be taken in electrolyte imbalances before using metocurine 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

metocurine is a non-depolarizing neuromuscular blocking agent (NMBA) that works by interfering with neuromuscular transmission at the neuromuscular junction. The receptors are activated by the neurotransmitter acetylcholine, leading to muscle contraction. 

Pharmacodynamics 

When acetylcholine binds to the receptors, it triggers the opening of ion channels, allowing sodium ions to enter the muscle cell. This influx of sodium ions leads to muscle depolarization and contraction. 

Pharmacokinetics 

Absorption   

metocurine is administered intravenously i.e., directly introduced into the bloodstream.  

Distribution 

metocurine is distributed throughout the body. It binds to plasma proteins to varying degrees. 

Metabolism 

metocurine undergoes metabolism in the liver.  

Elimination and excretion 

metocurine are primarily excreted through the urine.

Adminstartion

Administration 

metocurine is administered through intravenous route. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: metocurine 

Why do we use metocurine? 

metocurine is frequently used during surgical procedures to facilitate surgical access and improve operative conditions.   

metocurine is a non-depolarizing neuromuscular blocking agent is used to controlled muscle relaxation and paralysis.