Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Dyrex, Chlorophos, Anthon, Trinex, Totalene, Trinex, Briten
Synonyms :
Trichlorfon, methyl chlorophos, metrifonato, metrifonatum
Class :
Acetylcholinesterase inhibitors, antihelminthic (veterinary)
Brand Name :
Dyrex, Chlorophos, Anthon, Trinex, Totalene, Trinex, Briten
Synonyms :
Trichlorfon, methyl chlorophos, metrifonato, metrifonatum
Class :
Acetylcholinesterase inhibitors, antihelminthic (veterinary)
Dosage Forms & Strengths
Tablet
7.5mg
15mg
2.5
mg/kg
Tablets
Orally
once a day
2
weeks
Off-label/br
Loading dose: 2.5mg/kg orally for two weeks
Maintenance dose: 1mg/kg orally for two weeks
Data not available
Refer to adult dosing
may increase the hypoglycemic effect of Sulfonylurea
the bradycardic activity of acebutolol may be increased
the risk of adverse effects may be increased
the neuromuscular blocking activity of aclidinium may be increased
the therapeutic activity of amantadine may be decreased
the therapeutic activity of butobarbital may be decreased
the bradycardic activity of carvedilol may be increased
the therapeutic activity of chlorpromazine may be decreased
the neuromuscular blocking activity of cocaine may be increased
the therapeutic activity of desoximetasone may be decreased
the therapeutic activity of dosulepin may be decreased
the therapeutic activity of escitalopram may be decreased
the bradycardic activity of esmolol may be increased
the therapeutic activity of flavoxate may be decreased
the therapeutic activity of gallamine triethiodide may be decreased
the therapeutic activity of hydrocortisone butyrate may be decreased
the therapeutic activity of hyoscyamine may be decreased
the bradycardic activity of propranolol may be increased
Actions and spectrum:
Metrifonate acts as a long-acting cholinesterase inhibitor
Frequency not defined
Pain in the abdomen
Flatulence
Leg cramps
Diarrhea
Nausea
Vomiting
Lowered heart rate
Dyspepsia
Black Box Warning
Do not receive neuromuscular blocking medications for at least two days after administration of metrifonate
Contraindication/Caution:
Contraindication:
Hypersensitivity
Pregnancy consideration:
USFDA pregnancy category: data not available
Lactation:
The data about the excretion of drugs into human milk is not known
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Limited data available
Pharmacodynamics:
Pharmacokinetics:
Limited data available
Absorption
Distribution
Metabolism
Elimination and excretion
Half-life:
2 hours
Administration:
Take metrifonate as advised by the doctor
Patient information leaflet
Generic Name: metrifonate
Why do we use metrifonate?
Metrifonate was formerly used as an anthelminthic in treating ascariasis, creeping eruption in humans, helminthiasis, ankylostomiasis, etc. It was also used to treat Alzheimer disease due to its cholinesterase inhibition property.
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