Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Baypen, Mezlin, Meige, Li Yang, Mezlocillin, Mezlocillin Carino.
Synonyms :
Class :
: Class: Antimicrobials and Antiviral drugs; Sub class: Penicillins
Brand Name :
Baypen, Mezlin, Meige, Li Yang, Mezlocillin, Mezlocillin Carino.
Synonyms :
Class :
: Class: Antimicrobials and Antiviral drugs; Sub class: Penicillins
Dosage forms and strengths:
Injectable powder SolutionÂ
Adult:Â
Mild/Moderate: A dose of 1.5-2 g IV or IM FOR every 6 hours is recommended.
Severe: A dose of Usual dose 3 g IV given for every 6 hours.Â
Mild/Moderate: A dose of 1-2 g IV or IM given in one dose and probenecid 1 g given orally at the time of dosing or before 30 minutes.Â
To start the surgery a dose of 4 g IV is given 30-90 minutes before or 4 g IV given 6hrs and 12hrs later.Â
A dose 4 g IV given as the umbilical cord is clamped and the second and third doses of 4 g should be given IV 4-8 hours after the first dose.Â
Dose reduction may be necessary.Â
Mild/Moderate: A dose of 1.5-2 g IV or IM FOR every 6 hours is recommended
Severe: A dose of Usual dose 3 g IV given for every 6 hours
Mild/Moderate: A dose of 1-2 g IV or IM given in one dose and probenecid 1 g given orally at the time of dosing or before 30 minutes
To start the surgery a dose of 4 g IV is given 30-90 minutes before or 4 g IV given 6hrs and 12hrs later
Dosage forms and strengths:
Injectable powder Solution Â
Pediatric:Â Â
For less than 1 week a dose of 75 mg per kg is given every 12hrs
For 1 week to less than 1 month a dose of 75 mg per kg is given every 6 to 8hrs
For 1 month and less than12 years: 50-75 mg per kg is given every 4hrs
For 12 years old the usual adult dose is followed
When mezlocillin combines with BCG vaccine, the mezlocillin reduces the anti-tumor activity of the vaccine.
When mezlocillin combines with cholera vaccine, the mezlocillin reduces the effects of the vaccine.
When mezlocillin combines with methotrexate, it increases the blood levels and affects the action of methotrexate.
When mezlocillin combines with typhoid vaccine, the mezlocillin reduces the effects of the vaccine.
When mezlocillin combines with amikacin, the mezlocillin reduces the effects of the drug.
When mezlocillin combines with amikacin liposome, the mezlocillin reduces the effects of the drug.
When mezlocillin combines with anisindione it may increase the risk of bleeding in patients with liver or hepatic impairment and in elderly.
When mezlocillin combines with chloramphenicol, the chloramphenicol reduces the effects of the mezlocillin.
When mezlocillin combines with demeclocycline, the demeclocycline reduces the effects of mezlocillin.
When mezlocillin combines with dicumarol it may increase the risk of bleeding in patients with liver or hepatic impairment and in elderly.
When mezlocillin combines with doxycycline, the doxycycline reduces the effects of mezlocillin.
When mezlocillin combines with entecavir, it increases the blood levels.
When mezlocillin combines with estradiol, the mezlocillin reduces the effects of the drug.
When mezlocillin combines with ethinyl estradiol, the mezlocillin reduces the effects of the drug.
When mezlocillin combines with gentamicin, the mezlocillin reduces the effects of the drug.
Mezlocillin may interfere with Indium oxyquinoline in-111 and show changes in test results.
When mezlocillin combines with kanamycin, the mezlocillin reduces the effects of the drug.
When mezlocillin combines with minocycline, combination of this may impact on action and effectives of minocycline.
When mezlocillin combines with mycophenolate mofetil, it decreases the blood levels.
When mezlocillin combines with mycophenolic acid, it decreases the blood levels.
When mezlocillin combines with netilmicin, combination of this may impact on action and effectives of netilmicin.
When mezlocillin combines with Oxytetracycline, the drug reduces the effects of mezlocillin.
When mezlocillin combines with pemetrexed, it increases the blood levels.
When mezlocillin combines with plazomicin, combination of this may impact on action and effectives of plazomicin.
When mezlocillin combines with sarecycline, the drug reduces the effects of mezlocillin.
Mezlocillin may interfere with Sodium iodide i-123 and show changes in test results.
When mezlocillin combines with tetracycline, the drug reduces the effects of mezlocillin.
When mezlocillin combines with tobramycin, the drug reduces the effects of tobramycin.
When mezlocillin combines with warfarin it may increase the risk of bleeding in patients with liver or hepatic impairment and in elderly.
bismuth subcitrate, metronidazole and tetracycline
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
When mezlocillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of mezlocillin
penicillins may enhance the hypokalemic effect of dichlorphenamide
When mezlocillin combines with azithromycin, the drug reduces the effects of action by synergism.
When mezlocillin combines with clarithromycin, the drug reduces the effects of action by synergism/antagonism.
When mezlocillin combines with dirithromycin, the drug reduces the effects of action by synergism/antagonism.
When mezlocillin combines with erythromycin, the drug reduces the effects of action by synergism/antagonism.
When mezlocillin combines with heparin, the drug effects heparin action by inhibiting the platelet aggregation.
When mezlocillin and probenecid combines, the probenecid may increase the plasma concentrations and affect renal tubular secretion of mezlocillin.
When mezlocillin combines with Troleandomycin, the drug reduces the effects of action by synergism/antagonism.
Adverse drug reaction:Â
Frequency definedÂ
1-3%Â
Skin reactionsÂ
EosinophiliaÂ
DiarrheaÂ
1-2%Â
LeukopeniaÂ
Frequency not definedÂ
HypokalemiaÂ
ConvulsionsÂ
NauseaÂ
VomitingÂ
AgranulocytosisÂ
Elevations of BUN and serum creatinineÂ
urticarial rashÂ
AngioedemaÂ
PruritusÂ
BronchospasmÂ
HypotensionÂ
AnaphylaxisÂ
Black Box Warning:Â
Some peÂople who get mono could get a rash. Also, theÂre may be issues with bleÂeding and clotting. A person with mono might have trouble with electrolytes like sodium or potassium. Plus, if they take certain meÂdicines like vecuronium, the drugs could make their muscles stay reÂlaxed longer than normal.Â
Contraindication/Caution:Â
ContraindicationsÂ
CautionsÂ
Pregnancy and Lactation:Â
Pregnancy:Â
Lactation:Â
Pharmacology:Â
Mezlocillin inteÂrferes with the last steÂp of bacterial cell wall formation. It attaches to ceÂrtain proteins within the cell wall calleÂd penicillin-binding proteins (PBPs). This triggers an eÂnzyme, autolysin, to break down the ceÂll wall. As a result, the bacterial ceÂll ruptures and dies. Mezlocillin may also block an autolysin inhibitor, allowing more cell wall breakdown.Â
Pharmacodynamics:Â
Mezlocillin works by stopping bacteÂrial cell walls from being made propeÂrly. It binds to special proteins called peÂnicillin binding proteins (PBPs). When Mezlocillin binds to theÂse PBPs, it prevents the cross-linking of peptidoglycan layers in the ceÂll wall. This makes the cell wall weÂaker and less sturdy. Because of this, the bacteria can’t handle changeÂs in osmotic pressure very weÂll. As a result, the bacterial ceÂlls burst open, and the bacteria dieÂ.Â
Pharmacokinetics:Â
DistributionÂ
The meÂdication connects with proteins in varied rangeÂs between 16% and 59%.Â
Elimination and ExcretionÂ
It stays active for different periods, from 1.3 to 4.4 hours. Around half eÂxits through urine.Â
Administration:Â
Mezlocillin eÂnters the body through IV infusion, straight into the bloodstreÂam. Its dose is tailored to the patieÂnt’s condition, weight, infection type and seÂverity. Treatment duration deÂpends on how serious the infeÂction is. Following the prescribed course is crucial. During treatment, healthcare providers closely watch the patieÂnt. They check for side eÂffects and monitor the responseÂ. The providers make adjustmeÂnts based on clinical and lab findings.Â
Patient Information LeafletÂ
An antibiotic called MeÂzlocillin works by bonding to cell wall proteins in bacteria. This stops   bacteÂria from living. Mezlocillin treats ear, bileÂ, and brain infections because it kills diffeÂrent types of bacteria. Both gram-positive and gram-negative bacteria are killed by Mezlocillin. HoweveÂr, side effects may occur like vomiting, diarrhea, constipation, hair loss, mouth sores, and nausea. ChildreÂn under two years old should not take MeÂzlocillin. People allergic to MeÂzlocillin, other medicines, or NSAIDs neÂed to be careful and teÂll their doctor right away. If you miss a dose, take it wheÂn you remember but do not double up or take too close to your next scheÂduled dose.Â
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