modafinil

Action and Spectrum

Drug Interaction

Adverse Reaction

Frequency defined:   

>10% 

Headache 

Decreased appetite 

Abdominal pain  

1% to 10% 

Chest pain 

Hypertension 

Palpitations 

Tachycardia 

Vasodilation 

Edema 

Nervousness 

Anxiety 

Dizziness 

Insomnia 

Depression 

Vasodilation 

Drowsiness  

Agitation  

Vertigo 

Hypertonia  

Chills  

Weight loss 

Increased thirst 

Anorexia  

Hepatic insufficiency 

Back pain 

Tremor 

Visual disturbance 

Rhinitis  

Pharyngitis  

Asthma 

Epistaxis   

Frequency not defined: 

Increased serum alkaline phosphatase 

Increased gamma-glutamyl transferase  

Postmarketing 

Angioedema 

Hepatotoxicity 

Aggressive behavior 

Agranulocytosis 

Delusion  

Hallucination  

Psychosis  

Skin rash  

Suicidal ideation  

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pregnancy consideration: Studies reported major congenital malformations following in utero exposure to modafinil.  

Lactation: Modafinil can be excreted in breast milk.  

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits These category drugs should be prohibited for pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Adminstartion

Patient Information Leaflet

Patient information leaflet 

Generic Name: Modafinil 

Pronounced: modafinil  

Why do we use modafinil? 

Modafinil is used to treat sleep apnea, narcolepsy, and other conditions related to daytime sleepiness.