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Brand Name :
Enerzair Breezhaler
Synonyms :
mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
Class :
Anticholinergic Agent, Long-Acting, Beta2 Agonist, Corticosteroid, Inhalant, Beta2-Adrenergic Agonist
Brand Name :
Enerzair Breezhaler
Synonyms :
mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
Class :
Anticholinergic Agent, Long-Acting, Beta2 Agonist, Corticosteroid, Inhalant, Beta2-Adrenergic Agonist
Dosage Forms & Strengths
Capsule
160 mcg/50 mcg/150 mcg
(mometasone/glycopyrrolate/indacaterol)
One capsule inhaled orally one time a day
Maximum dose not more than one capsule a day
Dosing modification
Renal Impairment
Dose modification not required
Hepatic impairment
Dose modification not required
Not suggested
Actions and Spectrum
mometasone acts as an anti-inflammatory agent, primarily used to reduce inflammation in the airways. It helps control and prevent symptoms in conditions such as asthma and chronic obstructive pulmonary disease (COPD) by decreasing swelling and mucus production in the air passages.
glycopyrrolate functions as a bronchodilator, which means it relaxes and widens the airways in the lungs. By blocking the action of acetylcholine, a neurotransmitter that causes smooth muscle contraction in the airways.
indacaterol acts as a bronchodilator by stimulating beta2-adrenergic receptors in the airways. This stimulation relaxes the smooth muscles in the bronchioles, leading to bronchodilation and improved airflow.
Frequency defined
<1%
Xerostomia
Hyperglycemia
Dysuria
Pruritus
Candidiasis
Skin rash
1-10%
Musculoskeletal pain
Cough
Urinary tract infection
Tachycardia
Gastroenteritis
Headache
Hypersensitivity reaction
Muscle spasm
Oropharyngeal pain
Fever
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
mometasone acts locally in the airways. It binds to glucocorticoid receptors, leading to the activation or repression of various genes involved in the inflammatory response.
glycopyrrolate works by blocking the action of acetylcholine at muscarinic receptors on the smooth muscles of the airways.
indacaterol binds to and stimulates beta2-adrenergic receptors. This receptor leads to relaxation of the bronchial smooth muscles, resulting in bronchodilation. In
Pharmacodynamics
mometasone inhibits the production of inflammatory cytokines and chemokines, suppresses the migration and activation of inflammatory cells, and reduces the synthesis of inflammatory mediators.
glycopyrrolate inhibits the actions of acetylcholine and it promotes bronchoconstriction and mucus secretion.
indacaterol stimulates the receptors, leading to the activation of adenylate cyclase and increased intracellular levels of cyclic adenosine monophosphate (cAMP).
Pharmacokinetics
Absorption
mometasone/glycopyrrolate/indacaterol all are administered via inhalation which ensures local delivery to the lungs.
Distribution
mometasone/glycopyrrolate/indacaterol are distributed through the bloodstream to various tissues.
Metabolism
mometasone undergoes extensive hepatic metabolism while glycopyrrolate/indacaterol undergoes limited metabolism in the liver.
Elimination and excretion
mometasone/glycopyrrolate/indacaterol all are excreted mainly through the renal route in urine and feces.
Administration
mometasone is available in various formulations, including inhalers and nasal sprays. While glycopyrrolate/indacaterol are administered via inhalation and they are usually available as a dry powder inhaler (DPI) or a solution for nebulization.
Patient information leaflet
Generic Name: mometasone/glycopyrrolate (glycopyrronium)/indacaterol
Why do we use mometasone/glycopyrrolate (glycopyrronium)/indacaterol?
mometasone/glycopyrrolate/indacaterol each of these drugs specifically uses for the management of various respiratory conditions.
mometasone/glycopyrrolate/indacaterol inhalers are used for maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD).
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