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Brand Name :
Myoden, Adenoscan, Adenocard
Synonyms :
adenosine
Class :
Group V antiarrhythmics Cardiac stressing agents
Brand Name :
Myoden, Adenoscan, Adenocard
Synonyms :
adenosine
Class :
Group V antiarrhythmics Cardiac stressing agents
Dosage forms and strengths Â
Intravenous solutionÂ
300 mcg/50 mLÂ
3 mg/mLÂ
25 mg/mLÂ
Supraventricular Tachycardia (SVT)Â
The recommended starting dose is administration of 6 mg intravenous bolus for 1-2 seconds
Repeated dose- If supraventricular tachycardia is not cured after the first dose in one to two minutes
Administer 12 mg intravenous bolus given for 1-2 seconds; repeat if necessary
The maximum recommended dose is 12 mg
Wolff-Parkinson-White SyndromeÂ
The recommended starting dose is administration of 6 mg intravenous bolus for 1-2 seconds
Repeated dose- If supraventricular tachycardia is not cured after the first dose in one to two minutes
Administer 12 mg intravenous bolus given for 1-2 seconds; repeat if necessary
The maximum recommended dose is 12 mg
Dosage forms and strengths Â
Intravenous solutionÂ
300 mcg/50 mLÂ
3 mg/mLÂ
25 mg/mLÂ
Supraventricular Tachycardia (SVT)Â
Weight <50 KG-
The recommended starting dose is administration of 0.05 -0.1 mg/kg mg intravenous bolus for 1-2 seconds
Repeated dose- If supraventricular tachycardia is not cured after the first dose in one to two minutes
continue at elevated dosages, ranging from 0.05-0.1 mg/kg, until sinus rhythm is achieved or the maximum one dose is reached
Weight>50 Kg/more-
The recommended starting dose is administration of 6 mg intravenous bolus for 1-2 seconds
Repeated dose- If supraventricular tachycardia is not cured after the first dose in one to two minutes
Administer 12 mg intravenous bolus given for 1-2 seconds; repeat if necessary
The maximum recommended dose is 0.3 mg/kg & 12 mg
Refer adult dosingÂ
may increase the toxic effect of dipyridamole
may enhance the arrhythmogenic activities of each other when combined
it may enhance the risk of QTc prolongation when combined with amifampridine
Combining xamoterol with adenosine may elevate the risk/seriousness of tachycardia
When ponesimod is used together with adenosine, this leads to enhanced risk or seriousness of bradycardia
When adenosine is used together with givinostat, this leads to enhanced risk or severity of Qtc prolongation
adenosine: it may increase the risk or severity of CNS depression
adenosine: it may increase the risk or severity of CNS depression
adenosine: it may increase the risk or severity of CNS depression
adenosine: it may increase the risk or severity of CNS depression
adenosine: it may increase the risk or severity of CNS depression
adenosine may enhance the arrhythmogenic effects of prenylamine
combining adenosine with benzquinamide may raise the risk or degree of tachycardia
when both drugs are combined, there may be an increased risk or severity of QTC prolongation
may have an increased AV-blocking effect when combined with adenosine
may have an increased av-blocking effect when combined with adenosine
side effects of adenosine are increased by digitoxin
When acrivastine is used together with adenosine, this leads tob enhanced risk or seriousness of QTc prolongation
When alfuzosin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When alimemazine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When amantadine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When amifampridine is used together with adenosine, this leads tob enhanced risk or seriousness of QTc prolongation
When amisulpride is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When amitriptyline is used together with amitriptyline, this leads to enhanced risk or seriousness of QTc prolongation
When amodiaquine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When amoxapine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When anagrelide is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When antazoline is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When apomorphine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When arformoterol is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When ariprazole is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When arsenic trioxide is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When artemether is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When asenapine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When astemizole is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When atazanavir is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When atomoxetine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When azatadine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When azithromycin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When bedaquiline is used together with adenosine this leads to enhanced risk or seriousness of QTc prolongation
When benzatropine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When berotralstat is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When bilastine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When bortezomib is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When brompheniramine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When buclizine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When buserelin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When butriptyline is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When carbinoxamine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When ceritinib is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cetirizine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When chlorcyclizine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When chloroquine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When chlorpheniramine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When chlorpromazine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When chlorprothixene is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cilostazol is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cinoxacin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When ciprofloxacin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cisapride is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When citalopram is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When clarithromycin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When clemastine is used together with aenosine, this leads to enhanced risk or seriousness of QTc prolongation
When clofazimine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When clomipramine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When clozapine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cocaine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When crizotinib is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cyclizine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When cyproheptadine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When dabrafenib is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When dasatinib is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When degarelix is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When delafloxacin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When desflurane is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When desipramine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When desloratadine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When deutetrabenazine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When dexbrompheniramine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When dimenhydrinate is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When diphenhydramine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When disulfiram is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When dolasetron is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When domperidone is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When dosulepin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When doxepin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When doxylamine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When droperidol is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When ebastine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When efavirenz is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When emedastine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When encorafenib is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When enoxacin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When epinastine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When eribulin is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When erlotinib is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
the risk of tachycardia may be increased
the risk of tachycardia may be increased
the risk of tachycardia may be increased
the risk of tachycardia may be increased
The therapeutic effect of adenosine may be reduced by the presence of caffeine and caffeine Containing Products
May enhances the effects of the other by pharmacodynamic synergism
Actions and Spectrum:Â
Action:Â
Vasodilation: adenosine activates A2A and A2B receptors on blood vessel walls, leading to vasodilation. This action helps increase blood flow to various tissues, including the heart, which is important during periods of reduced oxygen supply.Â
Cardiovascular Effects: adenosine has cardioprotective effects, as it can help reduce heart rate, decrease myocardial oxygen demand, and improve coronary blood flow. It is sometimes used in cardiology to diagnose and treat certain heart conditions, such as supraventricular tachycardia.Â
Spectrum:Â
Cardiovascular System: adenosine is used in cardiology to treat certain arrhythmias, especially supraventricular tachycardia, due to its ability to slow down electrical conduction in the heart.Â
Frequency not defined Â
NauseaÂ
DizzinessÂ
HeadacheÂ
Chest discomfort/painÂ
DyspneaÂ
FlushingÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
hypersensitivity: adenosine should not be used in individuals who have a known hypersensitivity or allergy to adenosine or any of its components.Â
Second- or third-degree heart block: adenosine can slow down the electrical conduction in the heart, which may worsen heart block or other conduction disturbances. It should not be used in individuals with advanced heart block (second- or third-degree block) unless they have a functioning artificial pacemaker.Â
Sick sinus syndrome: adenosine may exacerbate sick sinus syndrome, a condition characterized by abnormal heart rhythms. It should be used cautiously in patients with this condition.Â
Severe hypotension: adenosine can cause a transient drop in blood pressure. It should be avoided in patients with severe hypotension, shock, or those who are critically ill.Â
Pregnancy and breastfeeding: The safety of adenosine in pregnant or breastfeeding women is not well established. It is important to carefully evaluate the benefits and potential risks, and to use it only when the benefits outweigh the potential risks.Â
Pregnancy warnings:    Â
Pregnancy category: AU TGA pregnancy category: B2
US FDA pregnancy category: CÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: adenosine is primarily used to treat certain heart rhythm disorders, particularly those related to supraventricular tachycardias (SVTs).Â
Pharmacodynamics:Â Â
Slows Heart Rate: adenosine activates A1 receptors in the atrioventricular (AV) node, leading to a reduction in AV node conduction. This results in a temporary slowing of the heart rate, making it useful in treating certain tachycardias.Â
Vasodilation: adenosine causes vasodilation in coronary arteries, leading to increased blood flow to the heart. This can help relieve angina symptoms. Â
Pharmacokinetics:Â
AbsorptionÂ
adenosine, when given intravenously, it quickly reaches the systemic circulation, making it readily available for its intended therapeutic effects.Â
DistributionÂ
adenosine is distributed throughout the body via the bloodstream. It can traverse the blood-brain barrier & affect various tissues and organs.Â
MetabolismÂ
adenosine undergoes rapid intracellular metabolism. It is primarily metabolized in red blood cells and endothelial cells.Â
Excretion and EliminationÂ
adenosine and its metabolites are excreted primarily through the kidneys. Â
Administration: Â
Before administering adenosine, a healthcare provider will assess the patient’s condition, including their heart rate and rhythm, medical history, and any contraindications or allergies. adenosine is administered as a rapid IV bolus.Â
Patient information leafletÂ
Generic Name: adenosineÂ
Why do we use adenosine? Â
adenosine is used medically to treat certain heart rhythm disorders. It can slow down the heart rate by acting on specific receptors in the heart. This property makes it useful in the diagnosis and treatment of certain arrhythmias.Â
adenosine can cause blood vessels to dilate (expand). This property is utilized in medical procedures like cardiac stress tests, where adenosine is administered to increase blood flow to the heart, helping diagnose coronary artery disease.Â
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