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Brand Name :
Fraxiparine, Fraxiparine Forte
Synonyms :
nadroparin
Class :
Anticoagulant, Anticoagulant, Low Molecular Weight Heparin
Dosage Forms & Strengths
Solution Prefilled Syringe
2850 units/0.3 ml
15200 units/0.8 ml
9500 units/ml
11400 units/0.6 ml
3800 units/0.4 ml
5700 units/0.6 ml
19000 units/ml
Administer initial dose of 86 anti-Xa units/kg intravenously once bolus and the maximum dose not more than 9500 anti-Xa units
Fixed dosing:
<50 kg: dose of 3800 anti-Xa units once intravenous bolus
≥100 kg: dose of 9500 anti-Xa units once intravenous bolus
Administer maintenance dose of 86 anti-Xa units/kg subcutaneously each 12 hours and the maximum total daily dose not more than 19000 anti-Xa units
Fixed dosing:
<50 kg: dose of 3800 anti-Xa units subcutaneously each 12 hours
≥100 kg: dose of 9500 anti-Xa units subcutaneously each 12 hours
For Patients with standard bleeding risk:
Administer dose of 171 anti-Xa units/kg subcutaneously one time a day
Fixed dosing:
40 to 49 kg: dose of 7600 anti-Xa units subcutaneously one time daily
≥90 kg: dose of 17100 anti-Xa units subcutaneously one time daily
For Patients with increased risk for bleeding:
Administer dose of 86 anti-Xa units/kg subcutaneously each 12 hours
Fixed dosing:
40 to 49 kg: dose of 3800 anti-Xa units subcutaneously each 12 hours
≥90 kg: dose of 8550 anti-Xa units subcutaneously each 12 hours
Safety and efficacy not determined
Refer to adult dosing
When nadroparin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
when used with nadroparin, andexanet alfa's therapeutic efficacy may be lowered
Actions and Spectrum
nadroparin works by inhibiting the activity of certain clotting factors in the blood, particularly factor Xa and thrombin.
By inhibiting them, nadroparin helps to prevent the formation of new blood clots and stabilizes existing clots.
Frequency not defined
Venous thrombosis
Skin necrosis
Calcinosis
Arterial thrombosis
Thromboembolism
Hypoaldosteronism
Priapism
Eosinophilia
Increased serum alanine aminotransferase
Hemorrhage
Thrombocythemia
Thrombocytopenia
Increased serum aspartate aminotransferase
Angioedema, hypersensitivity reaction
Nonimmune anaphylaxis
Injection site reaction
Osteopenia
Post marketing report
Skin rash
Urticaria
Pruritus
Erythema of skin
Headache
Migraine
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
nadroparin binds to antithrombin III (AT III), a natural anticoagulant in the body, and enhances its inhibitory effect on Factor Xa and thrombin.
Pharmacodynamics
nadroparin’s inhibition of thrombin helps stabilize existing blood clots and prevents them from growing.
nadroparin has a mild inhibitory effect on platelet activation, which further contributes to its anticoagulant action.
Pharmacokinetics
Absorption
nadroparin is absorbed into the bloodstream from the subcutaneous tissue.
Distribution
nadroparin circulates throughout the body, distributing to various tissues and organs.
Metabolism
nadroparin is not significantly metabolized by the body. Its primary mode of action is to bind to antithrombin III (ATIII) to exert its anticoagulant effect.
Elimination and excretion
The elimination of nadroparin primarily occurs through renal clearance.
Administration
nadroparin is a medication that is administered through subcutaneous injection.
It available in the form of pre-filled syringes with a needle for injection.
Patient information leaflet
Generic Name: nadroparin
Why do we use nadroparin?
nadroparin is used to prevent deep vein thrombosis, which is the formation of blood clots in the deep veins.
nadroparin is used as a preventive measure to reduce the risk of pulmonary embolism in high-risk patients.
nadroparin is used as an anticoagulant during hemodialysis procedures to prevent clotting in the dialysis.
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