Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
N/A
Synonyms :
norelgestromin
Class :
Contraceptive agents
Brand Name :
N/A
Synonyms :
norelgestromin
Class :
Contraceptive agents
Dosage forms and strengths Â
N/AÂ
Not indicatedÂ
Refer adult dosingÂ
triamcinolone acetonide/nystatin
may decrease the therapeutic effect of antifungal agents
may decrease the therapeutic effect of antifungal agents
methenamine/sodium salicylate/benzoic acid
may decrease the therapeutic effect of antifungal agents
may decrease the therapeutic effect of antifungal agents
may decrease the therapeutic effect of antifungal agents
When norelgestromin is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When acetaminophen is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When acetazolamide is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When alpelisib is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When aminoglutethimide is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When amobarbital is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When armodafinil is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When bexarotene is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When brexanolone is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When brivaracetam is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When butalbital is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When calcitriol is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When cannabidiol is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When cefradine is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When cerivastatin is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When chlorpromazine is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When clevidipine is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When clofibrate is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When clonazepam is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When clorazepic acid is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When cyclophosphamide is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When deferasirox is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When diazepam is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
When dicloxacillin is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
Actions and Spectrum:Â
Action:Â
Inhibition of Ovulation: Like other progestins, norelgestromin primarily suppresses ovulation. It does so by inhibiting the release of an egg from the ovaries, which is a crucial step in the menstrual cycle. Without ovulation, there is no egg available for fertilization.Â
Frequency not defined Â
Menstrual crampsÂ
NauseaÂ
HeadacheÂ
Skin reactionÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Known Hypersensitivity: Individuals with known hypersensitivity or allergy to norelgestromin or its components should not use the contraceptive patch.Â
Thromboembolic Disorders: norelgestromin has been linked to a heightened susceptibility to thromboembolic occurrences, including deep vein thrombosis and pulmonary embolism. Therefore, it is typically contraindicated in individuals with a history of these conditions.Â
Cardiovascular Disease: Women with a history of heart disease, stroke, angina, or other cardiovascular conditions may be at an increased risk when using norelgestromin, and its use should be carefully evaluated.Â
Major Surgery with Prolonged Immobilization: norelgestromin should be avoided in the postoperative period after major surgeries or during periods of prolonged immobilization due to an increased risk of thromboembolic events.Â
Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: norelgestromin is a synthetic progestin, which is a type of synthetic hormone that mimics the effects of the natural female sex hormone progesterone.Â
Pharmacodynamics:Â Â
Inhibition of ovulation: It inhibits the secretion of LH and FSH from the pituitary gland, thereby obstructing the development and release of an egg from the ovary.Â
Thickening of cervical mucus: norelgestromin makes the cervical mucus thicker, making it more difficult for sperm to penetrate and reach the egg. Â
Pharmacokinetics:Â
AbsorptionÂ
norelgestromin is absorbed through the skin when applied as a transdermal patch. It bypasses the gastrointestinal tract.Â
DistributionÂ
It is highly protein-bound in the bloodstream.Â
MetabolismÂ
norelgestromin is metabolized in the liver to its active metabolite norgestrel.Â
Excretion and EliminationÂ
The metabolites are primarily eliminated through urine and feces.Â
Administration: Â
The administration of norelgestromin should follow the instructions provided by a healthcare professional and those included in the medication’s packaging.Â
norelgestromin patches are available by prescription.Â
Patient information leafletÂ
Generic Name: norelgestrominÂ
Why do we use norelgestromin? Â
norelgestromin may be used in hormone replacement therapy for postmenopausal women, typically in combination with estrogen. Â
Besides preventing pregnancy, norelgestromin can provide other contraceptive benefits. It can make menstrual periods more regular, reduce menstrual cramps, and potentially alleviate symptoms like polycystic ovary syndrome (PCOS) and endometriosis.Â
Sometimes, norelgestromin can regulate and manage irregular menstrual cycles, heavy menstrual bleeding (menorrhagia), or other menstrual disorders.
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