New Long-Read Genetic Test Enables Faster and More Comprehensive Diagnosis of Rare Diseases
November 18, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Ocuflox
Synonyms :
ofloxacin ophthalmic
Class :
Quinolones, Ophthalmic
Brand Name :
Ocuflox
Synonyms :
ofloxacin ophthalmic
Class :
Quinolones, Ophthalmic
Dosage Forms & Strengths
Ophthalmic Solution
0.3%
Indicated for Bacterial Conjunctivitis:
Days 1 and 2: 1 to 2 drops into the affected eye every 2-4 hours, then
Days 3-7: 1 to 2 drops four times daily
Dosage Forms & Strengths
Ophthalmic Solution
0.3%
Indicated for Bacterial Conjunctivitis:
<1 year: Not recommended
Days 1 and 2: 1 to 2 drops into the affected eye every 2-4 hours, then
Days 3-7: 1 to 2 drops four times daily
Refer adult dosing
Mechanism of action
The mechanism of action of ofloxacin involves the inhibition of bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for DNA replication, repair, and transcription. By inhibiting these enzymes, ofloxacin prevents the bacterial cells from dividing and multiplying, leading to their death.
Specifically, ofloxacin binds to the A subunit of bacterial DNA gyrase, which creates negative supercoiling in the DNA molecule. By binding to this subunit, ofloxacin prevents the DNA strands from being separated and processed during replication, causing the bacterial cells to die. Ofloxacin also inhibits topoisomerase IV, which separates daughter chromosomes during cell division. By blocking this enzyme, ofloxacin further prevents bacterial cell division and multiplication.
Spectrum
ofloxacin has broad-spectrum activity against many gram-negative and gram-positive bacteria, including Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Streptococcus pneumoniae, and Staphylococcus aureus. It is commonly used to treat various bacterial infections, such as urinary tract infections, respiratory tract infections, skin and soft tissue infections, and sexually transmitted infections.
Frequency undefined:
Conjunctival hyperemia
Foreign body sensation
Periocular edema
Photophobia
Stinging
Dryness
Transient ocular burning
Chemical keratitis
Blurred vision
Eye pain
Pruritis
Tearing
Contraindications
Caution
Pregnancy consideration: C
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
ofloxacin ophthalmic is an antibiotic medication used to treat eye infections caused by certain bacteria. It belongs to the fluoroquinolone class of antibiotics, which work by inhibiting the bacterial DNA gyrase enzyme, thereby preventing the bacteria from replicating and causing further infection
When applied to the eye, ofloxacin ophthalmic is absorbed into the eye tissues and works locally to kill bacteria that may be causing the infection. It is effective against various gram-positive and gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, and Pseudomonas aeruginosa
Pharmacodynamics
The pharmacodynamics of ofloxacin ophthalmic involves its ability to inhibit bacterial DNA replication and division, leading to the death of the bacteria causing the infection. It is effective against many bacterial strains and has a low risk of systemic side effects
Pharmacokinetics
Absorption
ofloxacin ophthalmic is a topical medication administered directly into the eye. When applied to the eye, it is absorbed into the ocular tissues, where it reaches high concentrations in the aqueous humor
Distribution
ofloxacin ophthalmic is primarily distributed in the eye tissues and aqueous humor. It has low systemic absorption and does not reach high concentrations in other body parts
Metabolism
ofloxacin ophthalmic is not metabolized in the body. It is primarily eliminated unchanged through the kidneys
Elimination/Excretion:
ofloxacin ophthalmic is eliminated from the body primarily through the kidneys. It has a short elimination half-life of approximately 3.5 hours, which means it is rapidly cleared from the body.ofloxacin ophthalmic is excreted from the body in the urine, with approximately 95% of the dose eliminated within 48 hours
Administration
Not for subconjunctival or direct injection into the eye’s anterior chamber; exclusively for ophthalmic usage. Do not contact the applicator’s tip with your fingers, eyes, or other objects.
Patient information leaflet
Generic Name: ofloxacin ophthalmic
Pronounced: [ oh-FLOX-a-sin-off-THAL-mik ]
Why do we use ofloxacin ophthalmic?
ofloxacin ophthalmic is an antibiotic medication used to treat bacterial eye infections. It is typically prescribed for the following conditions:
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
