olopatadine intranasal

Action and Spectrum

Actions and Spectrum 

olopatadine intranasal works by attaching to nasal tissues histamine H1 receptors and inhibiting histamine’s effects. The immune system’s release of the chemical histamine during an allergic reaction is what causes the symptoms of allergic rhinitis.  

olopatadine’s range of therapeutic effects is mostly targeted at allergic rhinitis symptoms. It helps to treat the seasonal or persistent allergic rhinitis symptoms of nasal congestion, sneezing, itching, and runny nose.

Drug Interaction

Adverse Reaction

Frequency defined  

<1% 

Anosmia  

Nasopharyngitis 

Influenza 

Throat irritation 

Hyposmia 

CPK elevation 

Dry mouth 

>10% 

Respiratory epistaxis (3-25%) 

Bitter taste (12.8%) 

1-10% 

Pharyngolaryngeal pain (2.2%) 

Headache (4.4%)   

Urinary tract infection (1.2%) 

Upper respiratory tract infection (2.6% pediatric) 

Postnasal drip (1.5%)  

Cough (1.4%) 

Upper respiratory tract infection in children (3%) 

Somnolence (1%) 

Epistaxis (3.2%) 

Fatigue (1%) 

Weight gain (1%) 

Depression (2%) 

Black Box Warning

Black Box Warning 

None  

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• People with history of known hypersensitivity or allergic reaction to olopatadine or any of its ingredients should not take the intranasal medication olopatadine. 

Caution: 

• Depending on the age group, the intranasal medication olopatadine’s safety and effectiveness may differ.  
• If someone with a medical problem like asthma, glaucoma, urinary retention, prostatic hypertrophy, or cardiovascular issues, you should use the intranasal medicine olopatadine with caution.  
• Since the safety of the drug in these circumstances may not be fully established, using olopatadine intranasally during pregnancy or breastfeeding should be reviewed with a healthcare provider. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

A selective histamine H1 receptor antagonist called olopatadine is also known as antihistamine. When administered intravenously, the medication has its desired pharmacological effects by interacting with nasal tissues’ histamine H1 receptors and preventing histamine’s action.  

olopatadine intranasal works by inhibiting the H1 receptors, preventing histamine from attaching to them and lessening the allergic reaction in the nasal passages. 

Pharmacodynamics 

olopatadine intranasal has stabilizing effects on mast cells. Histamine and other inflammatory mediators are released by mast cells, which play a critical part in allergic reactions.   

olopatadine, an intranasal drug, has vasoconstrictive qualities that can assist lessen nasal congestion and blood vessel dilating effects. 

Pharmacokinetics 

Absorption   

Following intranasal dosing, olopatadine is absorbed from the nasal mucosa. The medication is made to have a good local bioavailability in the nasal passages, allowing for effective targeting of allergic symptoms in that area.  

Distribution 

The body’s tissues get olopatadine intranasal in different ways. After intranasal treatment, there is typically low systemic distribution. 

Metabolism 

Through the cytochrome P450 enzyme system, olopatadine is largely metabolized in the liver via the CYP2D6 pathway. The metabolism of olopatadine intranasal can be influenced by genetic factors that affect CYP2D6 enzyme activity.   

Elimination and excretion 

olopatadine intranasal and its metabolites are primarily excreted through the urine. It has a short elimination half-life, typically between 5 and 8 hours. 

Adminstartion

Administration 

olopatadine intranasal drug is typically administered through the nose. The positioning is like standing or sitting upright with your head slightly tilted forward.  

Insert the tip of the nasal spray applicator into one nostril, aiming the spray towards the outer wall of the nasal passage. Avoid spraying directly onto the nasal septum.

Patient Information Leaflet

Patient information leaflet 

Generic Name: olopatadine intranasal 

Why do we use olopatadine intranasal? 

olopatadine intranasal is effective in alleviating the symptoms of allergic rhinitis, which may include sneezing, itching, runny nose, nasal congestion, and postnasal drip.   

olopatadine intranasal drug is particularly beneficial for individuals with seasonal allergies, such as those triggered by pollen from trees, grasses, or weeds. olopatadine intranasal is also effective in managing symptoms caused by perennial allergic rhinitis.