oxprenolol

Action and Spectrum

Actions and Spectrum 

oxprenolol is a non-selective beta blocker, meaning it blocks both beta-1 and beta-2 adrenergic receptors.  

Beta-1 receptors are primarily located in the heart and blocking them leads to a decrease in heart rate and force of contraction.  

By reducing the heart rate and the force with which the heart contracts, oxprenolol can effectively lower blood pressure.

Drug Interaction

Adverse Reaction

Frequency not defined  

Hypotension  

Fatigue 

Dizziness 

Heart failure 

Peripheral vascular disorders  

Dry mouth  

Constipation  

Headache  

Bronchoconstriction  

Nausea 

Dyspnea  

Skin rash 

Mental depression

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

oxprenolol should not be used in individuals who have a known hypersensitivity or allergic reaction to the medication or any of its components. 

oxprenolol is contraindicated in individuals with second-degree and third-degree heart block. 

Caution: 

Caution is necessary in individuals with thyroid disorders. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

oxprenolol decreases heart rate by blocking the stimulatory effects of epinephrine and norepinephrine on the heart’s beta-1 receptors. This can lead to a reduced heart rate. oxprenolol reduces the force of contraction of the heart muscle, leading to a decrease in the heart’s oxygen demand and workload. 

Pharmacodynamics 

oxprenolol’s antagonism of beta receptors can help stabilize heart rhythm by decreasing the sensitivity of the heart to sympathetic stimulation. This can be especially beneficial in certain arrhythmias like atrial fibrillation and supraventricular tachycardia. 

Pharmacokinetics 

Absorption   

oxprenolol is absorbed from the gastrointestinal tract after oral administration. 

Distribution 

oxprenolol is distributed throughout the body’s tissues. 

Metabolism 

oxprenolol undergoes significant metabolism in the liver through oxidative pathways involving enzymes such as cytochrome P450 enzymes. 

Elimination and excretion 

oxprenolol is excreted primarily in the urine. 

Adminstartion

Administration 

oxprenolol is usually administered orally in the form of tablets.

Patient Information Leaflet

Patient information leaflet 

Generic Name: oxprenolol 

Why do we use oxprenolol? 

oxprenolol is used in the management of angina pectoris and hypertension.  

oxprenolol can be effective in stabilizing heart rhythm by blocking certain arrhythmia triggers.