pentazocine/acetaminophen

Action and Spectrum

Action and spectrum:  

Pentazocine/acetaminophen is a combination of two drugs which relieves pain. 

Pentazocine is an opioid that works on opioid receptors and acetaminophen is an analgesic that relieves pain by preventing the production of certain chemicals. 

Drug Interaction

Adverse Reaction

Frequency Not Defined 

For Pentazocine 

Circulatory depression 

Depression 

Floating feeling 

Cramps  

Nausea, vomiting 

Abdominal distress 

Apprehension 

Confusion and hallucinations 

Constipation 

Blurred vision 

For Acetaminophen 

Angioedema 

Pruritic maculopapular 

Urticaria 

Agranulocytosis, leukopenia 

Thrombocytopenic purpura 

Hepatotoxicity 

Black Box Warning

Black box warning  

None  

Contraindication / Caution

Contraindication and caution  

Contraindications 

• Hypersensitivity 
• Pseudomembranous enterocolitis 

Cautions 

• Acute asthma 
• Bradycardia 
• Chronic respiratory disease 
• Liver disease 
• Epilepsy 

Pregnancy / Lactation

Pregnancy Warnings: 

Pregnancy category:  C (pentazocine) 

Lactation: Excretion of the drug into the human breast milk is unknown 

Pregnancy categories: 

Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester. 

Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women. 

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women. 

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology:  

Pentazocine is an opioid agonist which causes changes in response to pain. 

While acetaminophen is a nonsalicylate analgesic which may block pain impulses.  

Pharmacodynamics:  

Limited information is available.  

Pharmacokinetics:  

Limited data is available on ADME as drug is discontinued.   

Adminstartion

Administration:  

It is taken orally in the form of tablets.   

Patient Information Leaflet

Patient information leaflet  

Generic Name: pentazocine/acetaminophen 

Why do we use pentazocine/acetaminophen?  

Pentazocine/acetaminophen is a combination drug used to treat mild-to-moderate pain.