Impact of High-Pillow Sleeping Posture on Intraocular Pressure in Glaucoma
January 28, 2026
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Brand Name :
Definity, Definity RT, Optison
Synonyms :
perflutren
Class :
Diagnostic imaging agents, ultrasound contrast media
Brand Name :
Definity, Definity RT, Optison
Synonyms :
perflutren
Class :
Diagnostic imaging agents, ultrasound contrast media
Dosage Forms & Strengths
Injectable Suspension
Definity
Use only after activating the product
IV Bolus: 10 mcl/kg over 30–60 seconds, followed by administration of 10 ml flush of saline; repeat the dose and flush a second time, if needed, after 30 minutes
Intravenous 1.3 ml in 50 mL of NS 0.9% NaCl (preservative-free) is the infusion amount; start the IV at 4 ml/min and titrate PRN, not to go over 10 ml/minute
Optison
0.5 ml intravenous bolus; drip slowly into a peripheral vein, not to exceed 1 mL/sec; cleanse with D5W or 0.9% NaCl.
Extra doses of 0.5 ml may be administered to improve imaging quality.
Take, at most, five milliliters in total in ten minutes.
To be at most 8.7 ml cumulative dose/study for each patient.
Data not available
Refer to adult dosing
QTc interval is increased both by lenvatinib and perflutren
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
the risk of QTc prolongation may be increased
Actions and spectrum:
Frequency defined
Prolongation on QTc(>10%)
Nausea (1-4.3%)
Dizziness (0.62%)
Chills (1.4%)
Dyspnea (1.1%)
Flu-like symptoms (1.1%)
Malaise (1.1%)
Headache (2.3-5.4%)
Black Box Warning
Severe cardiopulmonary events, including death, may happen. So, make sure that resuscitation equipment and personnel will be available readily.
Contraindication/Caution:
Contraindication:
Hypersensitivity
Long-lasting pulmonary vascular disorder
Pregnancy consideration:
USFDA pregnancy category: not assigned
Lactation:
Data about the excretion of drugs into breast milk is not known.
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Pharmacodynamics:
Pharmacokinetics:
Limited data available
Absorption
Distribution
Metabolism
Elimination and excretion
Half-life:
1.9minutes
Administration:
Administer the drug immediately after reconstitution
Patient information leaflet
Generic Name: perflutren
Why do we use perflutren?
Perflutren is used as a diagnostic imaging agent in echocardiography.
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