The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
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Brand Name :
Acelex
Synonyms :
polmacoxib
Class :
Anti-inflammatory, NSAID, Selective COX2 inhibitor
Brand Name :
Acelex
Synonyms :
polmacoxib
Class :
Anti-inflammatory, NSAID, Selective COX2 inhibitor
Dosage Forms & StrengthsÂ
TabletÂ
2 mgÂ
It is employed for the management of knee and hip joint osteoarthritis
The advised daily dosage is 2mg via oral administration, to be taken once daily following a meal
The total daily intake should not surpass 2 mg
If no therapeutic advantages are observed at the recommended dosage, discontinuation of this medication is advised, and suitable alternative treatment should be explored
Dose Adjustments
Limited data is available
Not determined Â
Refer to the adult dosing
betrixaban the chances of bleeding may be increased when betrixaban is combined with polmacoxib
bimatoprost the effectiveness of bimatoprost may be reduced when used concurrently with polmacoxib
benzthiazide the effectiveness of benzthiazide may be reduced when used concurrently with polmacoxib
benzydamine the chances of adverse effects may be increased when benzydamine is combined with polmacoxib
bepridil the therapeutic efficacy of bepridil may be decreased when used in combination with polmacoxib
betamethasone, the chances of gastrointestinal irritation may be increased when betamethasone is combined with polmacoxib
betaxolol polmacoxib may diminish the antihypertensive activities of betaxolol
betulinic acid the chances of adverse effects may be increased when polmacoxib is combined with betulinic acid
Action and spectrum:Â
Polmacoxib inhibits enzymes involved in inflammation, which decreases the synthesis of proinflammatory chemicals called prostaglandins.Â
Frequency not definedÂ
HeadacheÂ
Upset stomachÂ
NauseaÂ
Black box warningÂ
None Â
Contraindication/Caution:Â
The drug is contraindicated in the following situations:Â Â
HypersensitivityÂ
Allergic to sulfonamidesÂ
Renal impairmentÂ
Liver failureÂ
Pregnancy Warnings:Â Â
Pregnancy category: N/AÂ Â
Lactation:Â Â
Excretion of the drug in human breast milk is unknown Â
Pregnancy categories:Â Â Â Â
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.   Â
<b>Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.   Â
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.   Â
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.   Â
Category N: There is no data available for the drug under this category.Â
Pharmacology:Â
It inhibits the carbonic anhydrase subtypes and cyclooxygenase 2 (COX-2) inhibitors. Â
Pharmacodynamics:Â
This drug selectively inhibited COX-2 over COX-1 in human tissue cells, including platelets, peripheral blood monocytes, and blood. Â
Pharmacokinetics:Â
Limited information is available on ADME. Â
Administration:Â
Polmacoxib is available in oral dosage forms. Â
Patient information leafletÂ
Generic Name: polmacoxibÂ
Why do we use polmacoxib?Â
It is indicated in the treatment of osteoarthritis of knee and hip joints.Â
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