potassium phosphate/sodium acid phosphate

Action and Spectrum

Actions and Spectrum 

Acidic compounds include sodium acid phosphate and potassium phosphate. They make the urine more acidic when taken orally. By dissolving or delaying the crystallisation of calcium phosphate and struvite, this increased acidity aids in preventing the formation of these stones. 

The medicine combination aids in bringing the pH of the urine closer to that of the blood. This is significant because urine that is alkaline tends to promote the formation of specific kidney stone forms, such as calcium phosphate and struvite stones.  

The effectiveness of potassium phosphate/ sodium acid phosphate in treating various kidney stone forms is referred to as the spectrum. In this instance, calcium phosphate and stones, which frequently occur in alkaline urine, are the main targets of the medicine combination. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Confusion 

Low urine output 

Dizziness 

Mild laxative effect 

Tachycardia 

Numbness or tingling 

Shortness of breath 

Headache 

Weakness or heaviness of legs 

Weight gain 

Thirst 

Lower extremity swelling 

Gastrointestinal upset 

Black Box Warning

Black Box Warning 

potassium phosphate/sodium acid phosphate does not have any black box warning. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• This prescription should not be taken by anyone who has a known hypersensitivity to sodium acid phosphate/potassium phosphate, or any other component of the drug. 

Caution: 

• Patients with renal impairment or a history of kidney disease are urged to exercise caution. The acidifying effects of the medication may make renal function worse. The need for careful renal function monitoring may arise. 
• Patients who already have electrolyte abnormalities, such as hyperkalemia or hypophosphatemia, should be handled carefully. 
• In individuals who have a history of gastric ulcer, inflammatory bowel disease, or other gastrointestinal diseases, caution is advised because the medication may induce gastrointestinal irritation. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: C 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

They raise the acidity of the urine when taken orally. Some kidney stone types, like calcium phosphate and stones, can be broken up or avoided by this acidity. 

By changing the pH of the urine to a more acidic level, the medicine combination works. This is significant because urine that is too alkaline can lead to the formation of certain kidney stones. 

Pharmacodynamics 

The body’s electrolyte levels may be influenced by the drug combination. It might improve the excretion of phosphate ions from the body through the urine, which might result in lower serum phosphate levels.  

The medicine prevents these sorts of stones from precipitating and crystalizing by maintaining an acidic pH, and in rare situations, it may also help dissolve already-formed stones. 

Pharmacokinetics 

Absorption   

The medicine combination is normally taken orally, and the gastrointestinal tract is where it is absorbed. 

Depending on the formulation and brand name, absorption may change. The systemic circulation is filled with sodium acid phosphate and potassium phosphate. 

Distribution 

The drug’s active ingredients are dispersed throughout the body after absorption. 

As the medicine reaches the systemic circulation, distribution is likely to be extensive. 

Metabolism 

In the body, potassium phosphate/sodium acid phosphate experiences little to no metabolic activity. 

Elimination and excretion 

The renal pathway accounts for the majority of potassium phosphate/sodium acid phosphate excretion. 

The drug’s acidifying effects in the urinary system are mostly achieved by urine excretion. 

Adminstartion

Administration 

Usually, the medicine combination is taken orally. It is available tablets, capsules, or oral solutions. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: potassium phosphate/sodium acid phosphate  

Why do we use potassium phosphate/sodium acid phosphate? 

The main purposes of potassium phosphate/ sodium acid phosphate are the prevention and treatment of certain kidney stones.   

The medicine combination aids in generating an acidic environment in the urine, which can breakdown calcium phosphate and stone formation or prevent it.