- March 15, 2022
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Brand Name :
Synonyms :
Class :
Antimalarials; 8-Aminoquinoline
Dosage forms & Strengths:
Adult:
Tablet:
26.3 mg
30 mg base (with 52.6 mg salt) orally each day for 14 days
Alternatively, 45 mg base with 78.9 mg salt, orally every week for 8 weeks
primaquine removes any dormant hypnozoites that are present in the liver causing malarial relapse
Administer the drug with other antimalarial agents as it is inactive against plasmodial asexual erythrocytic forms
Uncomplicated Malaria
(Off-Label)
30 mg orally each day for 14 days in combination with hydroxychloroquine chloroquine
Also, for moderate G6PD deficiency as a substitute
45 mg orally every week for 8 weeks
Chemoprophylaxis
(Off-label)
In P. ovale and P.vivax malaria, 30 mg orally each day for 14 days after leaving the endemic area
P. jiroveci Pneumonia
(Orphan)
15-30 mg orally each day for 21 days (combined with oral or intravenous clindamycin)
Prophylaxis of Malaria
0.5 mg/kg base with 0.8 mg/kg salt orally each day
Keep 30 mg as the base dose
As a prevention, take the dose 1-2 days prior to traveling to a malaria-prone area until 7 days post leaving the area
Utilized mainly for P. vivax infection
Pneumocystis Pneumonia
0.3 mg/kg base with 0.526 mg/kg salt orally each day
30 mg base should be kept as the maximum dose
Continue the medication for 21 days
Chemoprophylaxis
0.5 mg/kg each day; start the medication 1-2 days before traveling to the malaria-prone area and continue for 7 days after departure
Uncomplicated Malaria
(Off-Label)
0.5 mg/kg each day for 14 days in combination with hydroxychloroquine or chloroquine
may enhance the risk of adverse effect of dapsone
It may enhance the metabolism when combined with dexamethasone
it may enhance the risk of QTc prolongation when combined with amifampridine
when both drugs are combined, there may be an increased risk or severity of QTC prolongation
the effect of isradipine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
>10%:
Abdominal pain
Hemolytic anemia in G6PD deficiency
Nausea
Vomiting
1-10%:
Methemoglobinemia
<1%
Agranulocytosis
Arrhythmias
Headache
Leukopenia
Leukocytosis
Rash
Dizziness
Pruritus
Primaquine is contraindicated in people hypersensitive to it.
Pregnancy consideration:
Not suitable for pregnant females
Breastfeeding warnings:
Lactating mothers should not breastfeed during the therapy
Pregnancy category:
Patient information leaflet
Generic Name: primaquine
Pronounced: prahy-muh-kween
Why do we use primaquine?
Primaquine treats malaria.
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