procaterol

Action and Spectrum

Actions and Spectrum 

procaterol’s primary action is to relax and dilate the smooth muscles of the bronchial airways. This relaxation leads to an expansion of the airways, making it easier for individuals to breathe.

Drug Interaction

Adverse Reaction

Frequency not defined  

Increased blood pressure 

Acute asthma episodes  

Palpitations 

Exacerbated heart disease 

Shock 

Anaphylactoid reactions 

Tinnitus 

Nausea  

Dry mouth 

Gastric discomfort  

Muscle spasticity 

Headache  

Tremors 

Dizziness 

Numbness of limbs 

Drowsiness 

Insomnia 

Nasal congestion 

Rash 

Pruritus 

Cold sweat 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who have a known hypersensitivity or allergy to procaterol or any of its components should not use this medication.  

Caution: 

• Individuals with diabetes should use it with caution and monitor their blood sugar levels closely while taking the medication. 
• Individuals with a history of seizure disorders should be monitored closely. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

procaterol acts as a selective beta-2 adrenergic receptor agonist. These receptors are predominantly found in the smooth muscles of the bronchial airways. procaterol binds to beta-2 adrenergic receptors, it activates a signaling pathway that leads to smooth muscle relaxation. 

Pharmacodynamics 

Increased levels of cAMP within the smooth muscle cells activate protein kinase A, an enzyme that regulates muscle tone. 

Activation of PKA leads to the phosphorylation of specific proteins, including myosin, which ultimately results in relaxation of the smooth muscle. 

Pharmacokinetics 

Absorption   

procaterol is rapidly absorbed through the respiratory mucosa. 

Distribution 

procaterol is distributed to the lungs.  

Metabolism 

procaterol undergoes metabolism primarily in the liver. 

Elimination and excretion 

procaterol is excreted through the kidneys in the form of urine. 

Adminstartion

Administration 

procaterol is administered via inhalation using a metered-dose inhaler (MDI) and as a nebulized solution.  

Patient Information Leaflet

Patient information leaflet 

Generic Name: procaterol 

Why do we use procaterol? 

procaterol is used for the treatment of respiratory conditions characterized by bronchoconstriction and airway obstruction.  

procaterol is also used in the management of COPD, which includes conditions like chronic bronchitis and emphysema.