propiomazine

Action and Spectrum

Actions and Spectrum:   

This drug used to inhibiting the action of dopamine receptors in psychotic disorders. It also acts by blocking the histamine H1 receptor and may contribute to its use as a sedative.   

Spectrum of Activity:   

It acts as antiemetic and sedative. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Dystonia 

Athetoid movements 

Drowsiness 

Akathisia 

Black Box Warning

Black box warning: 

None 

Contraindication / Caution

Contraindications/caution:   

Contraindications:   

• Hypersensitivity or Allergy:   
• Coma  
• CNS Depression  
• Substance Abuse  

Caution:   

• CNS depression   
• Hepatic impairment   
• Renal impairment  

Pregnancy / Lactation

Pregnancy warnings:  

Pregnancy category: Not available   

Lactation: Excretion of the drug into human breast milk is unknown 

Pregnancy Categories:   

Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.   

<b>Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.   

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.   

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.   

Category N: There is no data available for the drug under this category.   

Pharmacology

Pharmacology:   

Propiomazine has sedative properties which inhibit the action of specific neurotransmitter receptors. 

Pharmacodynamics:   

It involves inhibiting dopamine receptors and alpha-adrenergic receptors action. 

Pharmacokinetics:   

Absorption: It is rapidly absorbed through GIT tract.  

Distribution: The drug is distributed widely in blood stream and its VD is 4 to 8 L/kg.  

Metabolism: It involves in hepatic metabolism  

Elimination and excretion: The drug gets excreted through the kidneys. Half-Life: 10 to 12 hours  

Adminstartion

Administration: 

Oral administration. Propiomazine is administered at night due to the sedative effects. 

Patient Information Leaflet

Patient information leaflet   

Generic Name: propiomazine   

Why do we use propiomazine?   

Propiomazine has the properties of antiemetic and sedative which is helpful in treating insomnia and vomiting.