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Brand Name :
Mictoryl, Mictoryl Pediatric
Synonyms :
propiverine
Class :
Anticholinergic Agent
Brand Name :
Mictoryl, Mictoryl Pediatric
Synonyms :
propiverine
Class :
Anticholinergic Agent
Dosage Forms & Strengths
Capsule (Extended Release)
30 mg
45 mg
Tablet
5 mg
Take an initial dose of 30 mg one time a day and it may raise up to 45 mg one time a day
Dosage Forms & Strengths
Tablet
5 mg
for Children and Adolescents:
Take a daily dose of 0.8 mg/kg orally in 2 divided doses
Dose of 5 mg two twice a day for 12 to 16 kg
Dose of 5 mg in the morning and 10 mg in the evening for 17 to 22 kg
Dose of 10 mg twice a day for 23 to 28 kg
Dose of 10 mg in the morning and 15 mg in the evening for 29 to 34 kg
Dose of 15 mg twice a day for ≥35 kg
Refer to adult dosing
Actions and Spectrum
The action of propiverine involves its effect on the muscarinic receptors found in the bladder smooth muscle and other tissues.
By blocking these receptors, it reduces the involuntary contractions of the bladder, thereby increasing the bladder’s capacity.
Frequency not defined
Edema
Hypertension
Fatigue
Urinary incontinence
Hypotension
Bradycardia, chest pain
Dizziness, fatigue, headache
Palpitation
Sore throat
Dysuria
Abdominal distension
Urinary retention
Intestinal obstruction
Atrioventricular block
Confusion
Delirium, hallucination
Drowsiness, excitability
Insomnia, paralysis
Pruritus, skin rash
Impaired consciousness, restlessness
Abdominal pain
Constipation, dyspepsia
Urticaria, erythema
Polydipsia
Myoglobin increased, thrombocytopenia
Hypersensitivity
Back pain, dyskinesia
Diarrhea, nausea
Leukopenia
Increased creatine phosphokinase
Myalgia
Rhabdomyolysis
Eye pain
Glaucoma
Increased intraocular pressure
Increased blood urea nitrogen
Oculomotor disturbance
Accommodation disturbances
Increased creatinine clearance
Post marketing reports
Cough
Tinnitus
Renal insufficiency
Upper respiratory tract infection
Fever
Leukocytosis
Pain
Increased bronchial secretions
Dyschromia
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
propiverine has an antispasmodic action on bladder smooth muscle by blocking calcium influx and modifying intracellular calcium.
It also has anticholinergic activity, which leads to a decrease in intravesical pressure.
Pharmacodynamics
propiverine is a competitive antagonist of muscarinic receptors, particularly the M1, M2, and M3 subtypes.
These receptors are G-protein-coupled receptors that mediate the effects of acetylcholine, a neurotransmitter released by cholinergic nerve endings.
Pharmacokinetics
Absorption
propiverine is rapidly absorbed from the gastrointestinal tract.
Distribution
propiverine is distributed throughout the body via bloodstream.
Metabolism
propiverine undergoes extensive first-pass metabolism in the liver.
Elimination and excretion
propiverine are excreted primarily through the urine.
Administration
propiverine is orally administered, usually in the form of tablets or extended-release capsules.
Patient information leaflet
Generic Name: propiverine
Why do we use propiverine?
propiverine is indicated for the relief of urinary symptoms including sudden, strong need to urinate.
propiverine is primarily used for the treatment of overactive bladder (OAB) symptoms, which include urgency, frequency, and urge incontinence.
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