propiverine

Action and Spectrum

Actions and Spectrum 

The action of propiverine involves its effect on the muscarinic receptors found in the bladder smooth muscle and other tissues.  

By blocking these receptors, it reduces the involuntary contractions of the bladder, thereby increasing the bladder’s capacity.

Drug Interaction

Adverse Reaction

Frequency not defined  

Edema  

Hypertension  

Fatigue  

Urinary incontinence 

Hypotension  

Bradycardia, chest pain  

Dizziness, fatigue, headache  

Palpitation 

Sore throat 

Dysuria  

Abdominal distension 

Urinary retention 

Intestinal obstruction 

Atrioventricular block  

Confusion  

Delirium, hallucination 

Drowsiness, excitability  

Insomnia, paralysis  

Pruritus, skin rash 

Impaired consciousness, restlessness 

Abdominal pain 

Constipation, dyspepsia  

Urticaria, erythema 

Polydipsia 

Myoglobin increased, thrombocytopenia 

Hypersensitivity 

Back pain, dyskinesia 

Diarrhea, nausea 

Leukopenia 

Increased creatine phosphokinase 

Myalgia  

Rhabdomyolysis 

Eye pain  

Glaucoma 

Increased intraocular pressure 

Increased blood urea nitrogen  

Oculomotor disturbance  

Accommodation disturbances 

Increased creatinine clearance  

Post marketing reports  

Cough 

Tinnitus 

Renal insufficiency 

Upper respiratory tract infection 

Fever  

Leukocytosis 

Pain 

Increased bronchial secretions  

Dyschromia 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• propiverine should not be used in individuals with a known hypersensitivity or allergy to the medication or any of its components. 

Caution: 

• Individuals with moderate to severe renal impairment may need dose adjustments while taking propiverine. 
• Patients with certain gastrointestinal conditions, such as severe ulcerative colitis should use propiverine with caution. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

propiverine has an antispasmodic action on bladder smooth muscle by blocking calcium influx and modifying intracellular calcium.  

It also has anticholinergic activity, which leads to a decrease in intravesical pressure. 

Pharmacodynamics 

propiverine is a competitive antagonist of muscarinic receptors, particularly the M1, M2, and M3 subtypes.  

These receptors are G-protein-coupled receptors that mediate the effects of acetylcholine, a neurotransmitter released by cholinergic nerve endings.  

Pharmacokinetics 

Absorption   

propiverine is rapidly absorbed from the gastrointestinal tract. 

Distribution 

propiverine is distributed throughout the body via bloodstream. 

Metabolism 

propiverine undergoes extensive first-pass metabolism in the liver. 

Elimination and excretion 

propiverine are excreted primarily through the urine. 

Adminstartion

Administration 

propiverine is orally administered, usually in the form of tablets or extended-release capsules. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: propiverine 

Why do we use propiverine? 

propiverine is indicated for the relief of urinary symptoms including sudden, strong need to urinate.  

propiverine is primarily used for the treatment of overactive bladder (OAB) symptoms, which include urgency, frequency, and urge incontinence.