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Brand Name :
Pyralvex
Synonyms :
rhubarb extract/salicylic acid
Class :
Mucosal and analgesic
Brand Name :
Pyralvex
Synonyms :
rhubarb extract/salicylic acid
Class :
Mucosal and analgesic
Dosage Forms & Strengths
Solution
50 mg/10 mg
It should be applied to the ulcer or irritated denture area for 3 to 4 times daily with help of brush provided with it
It should be use only up to one week
Safety and efficacy are not established
Actions and Spectrum:
Action:
Salicylic acid breaks down into the connections between dead skin cells to efficiently exfoliate the skin by deeply penetrating the pores.
This action is aided by the antibacterial qualities of rhubarb extract. It fights bacteria that cause acne and reduces inflammation brought on by breakouts.
Frequency not defined
Superficial tooth discoloration
Bronchospasm
Asthma
Allergic reaction
Rash
Burning sensation
Urticaria
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Rhubarb extract/salicylic acid products should not be used in individuals with a known hypersensitivity to salicylates or any other component of the formulation.
Caution:
Patients with a history of gastrointestinal disorders should use with caution.
Caution is taken in patients with renal impairment.
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Anthraquinones promote fecal evacuation and accelerate bowel motions by stimulating the colon’s peristalsis. While treating constipation this effect is helpful.
Pharmacodynamics
In the colon, the anthraquinone glycosides in rhubarb extract are metabolized by bacteria. It produces active metabolites such emodin and rhein.
In the stratum corneum, the skin’s outermost layer, salicylic acid causes keratinocyte connections to break. This results in a keratolytic action.
Pharmacokinetics
Absorption
Rhubarb extracts are absorbed through the intestinal mucosa and enter systemic circulation.
Salicylic acid is absorbed from the gastrointestinal tract.
Distribution
Rhubarb extract metabolites are distributed throughout the body via systemic circulation.
Salicylic acid is distributed widely throughout the body, including various tissues and organs.
Metabolism
Salicylic acid undergoes extensive hepatic metabolism.
Excretion and Elimination
Rhubarb extracts are excreted primarily via renal elimination.
Salicylic acids are eliminated via renal excretion.
Administration
Rhubarb extract is administered orally in the form of solution and liquid extracts.
Patient information leaflet
Generic Name: rhubarb extract/salicylic acid
Why do we use rhubarb extract/salicylic acid?
Rhubarb extract contains antioxidants such flavonoids and phenolic components that may help reduce oxidative stress and neutralize free radicals.
Salicylic acid can exfoliate skin thus used to clear clogged pores and reduce acne marks.
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