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Brand Name :
Flumadine
Synonyms :
rimantadine
Class :
Antivirals
Brand Name :
Flumadine
Synonyms :
rimantadine
Class :
Antivirals
Dosage Forms & Strengths
Tablet
100mg
Syrup
50mg/5ml
Indicated for Influenza A Virus:
Treatment
100mg orally twice a day, typically within 48 hours of the onset of influenza symptoms. a disease
Prophylaxis
100mg orally twice a day
Indicated for Influenza A Virus:
Treatment
100mg orally twice a day, typically within 48 hours of the onset of influenza symptoms. a disease
Prophylaxis
100mg orally twice a day
Indicated for Influenza A Virus:
Treatment
100mg orally twice a day, typically within 48 hours of the onset of influenza symptoms. a disease
Prophylaxis
100mg orally twice a day
Indicated for Influenza A Virus:
Treatment
100mg orally twice a day, typically within 48 hours of the onset of influenza symptoms. a disease
Prophylaxis
100mg orally twice a day
Indicated for Influenza A Virus:
Treatment
100mg orally twice a day, typically within 48 hours of the onset of influenza symptoms. a disease
Prophylaxis
100mg orally twice a day
Take dose of 100 mg orally two times a day
Dosage Forms & Strengths
Tablet
100 mg
Syrup
50 mg/5ml
Indicated for Influenza A Virus:
Children 1-10 years and Children >10 years but <40 kg: 5 mg/kg orally every day or twice a day; not to exceed 150mg/day
Children over the age of 10 years weighing more than 40 kg: 100mg orally twice a day
For 1 to 9 years old:
Take a dose of 5mg/kg orally daily in 1 or 2 divided doses
Maximum dose should not be more than 150 mg daily
≥10 years old:
Take dose of 100 mg orally two times a day
Refer to adult dosing
may decrease the therapeutic effect of each other when combined
may decrease the therapeutic effect of each other when combined
may decrease the therapeutic effect of each other when combined
may decrease the therapeutic effect of each other when combined
may decrease the therapeutic effect of each other when combined
may diminish the therapeutic efficacy when combination
may diminish the therapeutic efficacy when combination
may diminish the therapeutic efficacy when combination
may diminish the therapeutic efficacy when combined
may diminish the therapeutic efficacy when combined
may diminish the therapeutic efficacy when combined
vibrio cholerae cvd 103-hgr strain live antigen
may diminish the therapeutic efficacy when combined
may diminish the therapeutic efficacy when combined
Actions and Spectrum
rimantadine primarily targets the influenza A virus by interfering with the viral replication process.
It does this by blocking a viral protein called M2 ion channel protein. Influenza A virus enters host cells through an endosomal pathway.
Frequency not defined
Seizure
Nausea
Vomiting
Abdominal pain
Xerostomia
Fatigue
Anorexia
Headache
Dizziness
Insomnia
Nervousness
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: C
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
The influenza A virus enters host cells through an endosomal pathway. rimantadine inhibits the function of this ion channel, preventing the release of viral genetic material into the host cell.
Pharmacodynamics
rimantadine reduces the number of infectious viral particles produced within the host cells, which limits the spread of the virus within the host.
Pharmacokinetics
Absorption
rimantadine is well absorbed from the gastrointestinal tract after oral administration.
Distribution
rimantadine is distributed throughout the body.
Metabolism
rimantadine undergoes minimal metabolism in the liver.
Elimination and excretion
rimantadine is eliminated through the kidneys.
Administration
rimantadine is administered orally in tablet and syrup form.
Patient information leaflet
Generic Name: rimantadine
Why do we use rimantadine?
rimantadine can be used to prevent influenza A infections.
rimantadine can also be used for the treatment of influenza A infections.
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