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Brand Name :
N/A
Synonyms :
saruplase
Class :
Thrombolytic agent
Brand Name :
N/A
Synonyms :
saruplase
Class :
Thrombolytic agent
Dosage Forms & Strengths
Intravenous solution
20 mg
60 mg
Administer dose of 20 mg as a bolus and then followed by dose of 60 mg infused over an hour
Not determined
Refer to adult dosing
Actions and Spectrum
The action of unglycosylated human-type high molecular weight single-chain urokinase-type plasminogen activator is primarily related to its ability to activate plasminogen.
Plasminogen is an inactive precursor that, when activated to plasmin, can break down fibrin clots into smaller fragments.
Frequency not defined
None
Black Box Warning
None
Contraindication/Caution:
None
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
None
Pharmacodynamics
None
Pharmacokinetics
Information not available on ADME.
Administration
Administration of saruplase is not available.
Patient information leaflet
Generic Name: saruplase
Why do we use saruplase?
Saruplase used in treatment of acute myocardial infarction.
Saruplase is a safe and effective as a thrombolytic agent and successfully conducted with open-label Practical Applicability of Saruplase Study (PASS).
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