Fame and Mortality: Evidence from a Retrospective Analysis of Singers
November 26, 2025
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Brand Name :
Livdelzi
Synonyms :
seladelpar
Class :
Peroxisome Activated Receptor (PPAR) Agonists
Brand Name :
Livdelzi
Synonyms :
seladelpar
Class :
Peroxisome Activated Receptor (PPAR) Agonists
Adult
Capsule
10 mg
Not determined
Peroxisome proliferator-activated receptors are nuclear hormone receptors with alpha, delta, and gamma members. It helps to regulates breakdown of fats, bile production, and development of adipose cell in metabolism.
Frequency defined:
1-10%
Abdominal pain
Nausea
Abdominal distension
Serum creatinine elevated
Headache
Dizziness
Fractures
<5%
Rash
Alopecia
Anemia
Dyspepsia
Cough
Drug interaction:
Monitor closely
abemaciclib: it may decrease the metabolism of seladelpar
acyclovir: it may decrease the excretion of seladelpar
adagrasib: it may decrease the metabolism of seladelpar
abrocitinib: it may decrease the metabolism of seladelpar
acenocoumarol: it may decrease the metabolism of seladelpar
None
Contraindications:
None
Cautions:
Fractures
Biliary obstruction
Liver test abnormalities
Pregnancy Warnings:
Pregnancy category: Â N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Seladelpar activates peroxisome proliferator-activated receptors which are related to lipid metabolism and glucose regulation. This is responsible to improved fatty acid oxidation and insulin sensitivity.
Pharmacodynamics:
Seladelpar reduces total bile acids and bile acid synthesis in PBC patients, associated with high alkaline phosphatase levels due to increased bile acid concentration in hepatobiliary disorders.
Pharmacokinetic:
Absorption:
The peak plasma time is 1.5 hours and steady state achieved on day 4.
Distribution:
Protein bound: >99%
It has large volume of distribution up to 133.2 L.
Metabolism:
It is metabolized with CYP2C9 enzyme.
Excretion and elimination:
Half-life: 3.8 to 6.7 hours
It has clearance up to 12 L/hr.
It is available in oral dosage form.
Generic Name: seladelpar
Why do we use seladelpar?
Seladelpar it is indicated in treatment of primary biliary cholangitis.
Seladelpar is used to reduce liver fat and inflammation in Non-Alcoholic steatohepatitis patients. It is under study for NASH patients to enhance liver health and reduce fibrosis.
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