A Milestone Moment: FDA Approves Addyi® for Hypoactive Sexual Desire Disorder in Postmenopausal Women
December 17, 2025
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Brand Name :
Rapaflo
(United States) [Available]Synonyms :
silodosin
Class :
Adrenergic alpha-1 antagonist
Brand Name :
Rapaflo
(United States) [Available]Synonyms :
silodosin
Class :
Adrenergic alpha-1 antagonist
Dosage Forms & Strengths
Capsule, Oral:
4 mg
8 mg
No safe and efficacious dose described
Refer to adult dosing
It may diminish the effect when combined with griseofulvin by CYP3A4 metabolism
It may enhance the effect when combined with miconazole vaginal by affecting CYP3A4 metabolism
nafcillin will decrease the effect of action of silodosin by affecting enzyme CYP3A4 metabolism.
lapatinib increases the effect of silodosin by altering the intestinal or hepatic CYP3A4 enzyme metabolism
may have an increased hypotensive effect when combined with antihypertensive agents
may have an increased hypotensive effect when combined with antihypertensive agents
may have an increased hypotensive effect when combined with antihypertensive agents
may have an increased hypotensive effect when combined with antihypertensive agents
may have an increased hypotensive effect when combined with antihypertensive agents
silodosin: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
silodosin: they may increase the hypotensive effect when combined with blood viscosity-reducing agents
silodosin: they may enhance the serum concentration of CYP3A4 Inhibitors
silodosin: they may enhance the serum concentration of CYP3A4 Inhibitors
silodosin: they may enhance the serum concentration of CYP3A4 Inhibitors
silodosin: they may enhance the serum concentration of CYP3A4 Inhibitors
silodosin: they may enhance the serum concentration of CYP3A4 Inhibitors
silodosin: they may enhance the serum concentration of glycoprotein IIa Inhibitors
silodosin: they may decrease the therapeutic effect of antipsychotics
silodosin: they may decrease the therapeutic effect of antipsychotics
silodosin: they may decrease the therapeutic effect of antipsychotics
silodosin: they may decrease the therapeutic effect of antipsychotics
silodosin: they may decrease the therapeutic effect of antipsychotics
silodosin: they may increase the hypotensive effect of antihypertensive agents
may increase the CNS depressant effect of CNS depressants
amiodarone: they may enhance the serum concentration of silodosin
Frequency defined:
>10%
Retrograde ejaculated
1% to 10%
Orthostatic hypotension
Dizziness
Headache
Insomnia
Weakness
Prostate-specific antigen increased
Diarrhea
Abdominal pain
Nasal congestion
Rhinorrhea
Sinusitis
<1% Postmarketing
Hepatic insufficiency
Hypersensitivity reaction
Pharyngeal edema
Pruritis
Swollen tongue
Syncope
Urticaria
Pregnancy consideration: Not enough studies available for silodosin; therefore not recommended as initial therapy in pregnant women.
Lactation: excretion of silodosin in breast milk is not known.
Pregnancy category:
Patient information leaflet
Generic Name: Silodosin
Pronounced: silodosin
Why do we use silodosin?
Silodosin is used for the treatment of enlarged prostate.
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