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Brand Name :
Drez S, Sufrate TP, Septiace
Synonyms :
sucralfate/tinidazole/povidone iodine
Class :
Antiseptic and Antibiotic agents
Brand Name :
Drez S, Sufrate TP, Septiace
Synonyms :
sucralfate/tinidazole/povidone iodine
Class :
Antiseptic and Antibiotic agents
Dosage Forms & Strengths
Powder
10 gm
40 gm
Ointment
15 gm
Apply sufficient quantity of ointment topically to the affected area of skin for 3 to 4 times daily
Dosage Forms & Strengths
Powder
10 gm
40 gm
Ointment
15 gm
For 13 to 18 years old:
Apply sufficient quantity of ointment topically to the affected area of skin for 3 to 4 times daily
Refer to adult dosing
Actions and Spectrum
sucralfate is an aluminium salt of sucrose sulfate. It works by forming a protective barrier or coating on the mucosal lining of the stomach and duodenum.
This protective barrier acts as a physical barrier against stomach acid, pepsin, and other irritants, promoting the healing of ulcers and reducing irritation in the gastrointestinal tract.
tinidazole is an antibiotic that is used to treat a variety of bacterial and protozoal infections. It works by interfering with the DNA structure and function of the microorganisms, leading to their destruction.
povidone iodine is an antiseptic and disinfectant that is used to kill or inhibit the growth of microorganisms on the skin and mucous membranes. It releases iodine, which has strong antimicrobial properties and can kill a wide range of pathogens, including bacteria, viruses, and fungi.
Frequency not defined
Burning
Irritation
Dry skin
Itching
Redness
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
When taken orally, sucralfate forms a thick, viscous, and adhesive gel-like substance in the stomach. This gel adheres to the damaged mucosal lining of the stomach and duodenum, creating a protective barrier against gastric acid, pepsin, and other irritants.
tinidazole is an antimicrobial medication that works by damaging the DNA structure and inhibiting the DNA repair mechanism of bacteria and protozoa.
povidone iodine releases free iodine, which has potent antimicrobial properties. It works by disrupting the structure and function of microbial cell walls and proteins, or inhibiting the growth of bacteria, viruses, and fungi.
Pharmacodynamics
sucralfate primarily acts by creating a protective barrier on the mucosal lining of the stomach and duodenum. This barrier adheres to the damaged or ulcerated areas, forming a physical shield against gastric acid, pepsin, and other irritants.
The pharmacodynamic effect of tinidazole is the eradication of the targeted microorganisms. It is effective against a wide range of bacterial and protozoal infections, and its effects are seen through the resolution of infection-related symptoms.
povidone iodine’s pharmacodynamic effect is the killing or inhibition of the growth of a broad spectrum of microorganisms, including bacteria, viruses, and fungi.
Pharmacokinetics
Limited information available on ADME.
Administration
sucralfate/tinidazole/povidone iodine is a combination medicine apply topically and available in the form of powder and ointment.
Patient information leaflet
Generic Name: sucralfate/tinidazole/povidone iodine
Why do we use sucralfate/tinidazole/ povidone iodine?
Sufrate TP (sucralfate/tinidazole/povidone iodine) is a combination drug used in the treatment of bacterial skin infections.
sucralfate is protectant which covers the damaged tissue and protects it against injury to facilitate healing.
tinidazole is an antibiotic and it kills the bacteria and other microorganisms that cause infections by damaging their DNA.
povidone iodine is an antiseptic, and it slowly releases iodine which kills or prevents the growth of infectious microorganism.
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