Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Tinidazole
Synonyms :
tinidazole
Class :
Antiparasitic agents, Nitroimidazoles
Brand Name :
Tinidazole
Synonyms :
tinidazole
Class :
Antiparasitic agents, Nitroimidazoles
Dosage Forms & StrengthsÂ
TabletÂ
250mgÂ
500mgÂ
Indicated for Amebic Liver Abscess:
2g/day orally for 3-5days
2g/day orally for two days or 1g orally every day for five days
Indicated for Amebiasis, Intestinal:
2g/day orally for three days
2g orally once
>3 years: 50mg/kg/day orally for three days; maximum 2g
<3 years: Safety and efficacy not established
Dosage Forms & StrengthsÂ
TabletÂ
250mgÂ
500mgÂ
Indicated for Amebic Liver Abscess:
>3 years: 50mg/kg/day orally for three days; maximum 2g
<3 years: Safety and efficacy not established
>3 years: 50mg/kg/day orally for three days; maximum 2g
<3 years: Safety and efficacy not established
Refer adult dosingÂ
may decrease the therapeutic effect of antibiotics
sodium picosulfate, citric acid, and magnesium oxideÂ
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may increase the toxic effect of tinidazole
it decreases the rate of elimination of pidotimod
the effect of fluorouracil is increased by tinidazole by reducing hepatic clearance value
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
may decrease the therapeutic effect of antibiotics
cyclophosphamide effect of action increased by affecting enzyme CYP3A4 metabolism.
when both drugs are combined, there may be a reduced level of serum concentration of tinidazole by a reduced rate of excretion 
it increases the effect or level of palbociclib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
tinidazole has the potential to reduce the rate of excretion of abacavir, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of aclidinium, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of acrivastine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of almasilate, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of almotriptan, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of alogliptin, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of amantadine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of ammonium chloride, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of amoxicillin, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of amrinone, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of apremilast, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of arformoterol, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of atorvastatin, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of azacitidine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of azathioprine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of baricitinib, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of benserazide, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of benznidazole, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of bepotastine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of bicisate, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of bisoxatin, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of brivaracetam, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of bromazepam, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of budesonide, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of capreomycin, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of chromium, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of cilostazol, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of cisplatin, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of clevidipine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of clomipramine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of clonazepam, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of colchicine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of dalfampridine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of deferiprone, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of delafloxacin, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of desipramine, potentially leading to an elevation in level of serum
tinidazole has the potential to reduce the rate of excretion of dextran, potentially leading to an elevation in level of serum
The excretory rate of ancestim may be reduced with tinidazole, which results in higher levels in serum
tinidazole excretion rate is decreased when ceftizoxime is used in combination, which leads to elevated serum level concentrations
Actions and Spectrum:Â
tinidazole is an antiprotozoal and antibacterial medication used to treat infections caused by protozoa and anaerobic bacteria. It works by disrupting the target organism’s DNA synthesis and replication processes, leading to its deathÂ
tinidazole has a broad spectrum of activity against anaerobic bacteria and protozoa, including:Â
Frequency definedÂ
1-10%Â
Weakness/fatigue/malaise (1-2%)Â
Dysgeusia (4-6%)Â
Headache (<1%)Â
Dizziness (<1%)Â Â
Anorexia (2-3%)Â
Dyspepsia (1-2%)Â
Vomiting (1-2%)Â
Constipation (<1%)Â
Nausea(3-5%)Â
Frequency not definedÂ
Leukopenia/neutropenia urineÂ
Tongue & AtaxiaÂ
Candida paresthesiaÂ
DiarrheaÂ
Darkened neuropathyÂ
Numbness overgrowthÂ
Convulsions discolorationÂ
Transient peripheral & transientÂ
Black box warning:Â
The U.S. Food and Drug Administration (FDA) has issued a black box warning for tinidazole regarding the potential risk of carcinogenicity in laboratory animals. Long-term animal studies have shown that high doses of tinidazole can cause liver tumors in mice and ratsÂ
Contraindications/caution:Â
Contraindications:Â
tinidazole is contraindicated in patients with a known hypersensitivity to the drug or its components. Additionally, tinidazole should not be used in patients with a history of hypersensitivity to other nitroimidazole derivatives, such as metronidazole. It is also contraindicated in the following conditions:Â
Caution:Â
Several cautions should be considered before using tinidazole. These include:Â
Pregnancy consideration: CÂ
Lactation: It can be excreted into breast milk, and its use during breastfeeding is not recommendedÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
tinidazole is a synthetic nitroimidazole antibiotic that is structurally related to metronidazole. It exerts its pharmacological effect by disrupting anaerobic microorganisms’ DNA synthesis and replication processes, leading to their deathÂ
Pharmacodynamics:Â
tinidazole is a synthetic antiprotozoal agent effective against Trichomonas vaginalis, Giardia duodenalis (G. lamblia), and Entamoeba histolytica. It works by disrupting these protozoa’s DNA synthesis and replication processes, leading to their deathÂ
tinidazole is ineffective against most strains of vaginal lactobacilli, which are beneficial bacteria that maintain a healthy vaginal environment. However, tinidazole can disrupt the average balance of vaginal flora and increase the risk of secondary infections, such as vaginal candidiasisÂ
Pharmacokinetics:Â
AbsorptionÂ
tinidazole is rapidly and completely absorbed after oral administration, with a bioavailability of approximately 100%. It can be taken with or without food, and food does not significantly affect absorption. Peak plasma concentrations are achieved within 2-4 hours after a single oral doseÂ
DistributionÂ
 tinidazole has a high volume of distribution (Vd) of approximately 50 L, indicating that it is widely distributed throughout the body. It is highly protein-bound (>99%), primarily to albumin. Â
MetabolismÂ
tinidazole is metabolized in the liver by oxidation and conjugation to form hydroxylated and glucuronidated metabolites. The metabolites are eliminated mainly in the urine and feces. The elimination half-life of tinidazole is approximately 12-14 hours. Â
Elimination and ExcretionÂ
tinidazole and its metabolites are eliminated mainly in the urine and feces, with approximately 50-60% of the dose excreted and 20-25% in the feces. Renal elimination is the primary route of elimination, and dosage adjustments are recommended for patients with renal impairmentÂ
Administration:Â
Patient information leafletÂ
Generic Name: tinidazoleÂ
Pronounced: [ tye-NYE-da-zole ]Â
Why do we use tinidazole?Â
tinidazole is a synthetic antiprotozoal agent that is used to treat a variety of infections caused by protozoa, including:Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
