suprofen

Action and Spectrum

Actions and Spectrum:

Action: Suprofen acts as a COX inhibitor. COX is crucial in synthesis of prostaglandins, which are some essential compounds that cause pain, inflammation and swelling within the body. Through the blockage of COX, suprofen lowers the production of prostaglandins, thereby lowering pain and inflammation.

Spectrum: Suprofen is mainly considered to have a broad range of its activity toward its therapeutic applications, anti-inflammatory and analgesic properties. It does not exert direct antimicrobial, antibacterial, or antiviral effects.

Drug Interaction

Adverse Reaction

Adverse Reaction  

Frequency not defined  

Hypersensitivity

Photophobia

Chemosis

Redness

Itching

Eye discomfort

Pain

Black Box Warning

Black Box Warning:

None

Contraindication / Caution

Contraindication/Caution:  

Allergy or Hypersensitivity

History of Asthma or Aspirin Sensitivity

Active Peptic Ulcer or Gastrointestinal Bleeding

Severe Liver or Kidney Dysfunction

Bleeding Disorders

Heart Failure or Hypertension

Pregnancy and Breastfeeding

Pediatric Use

Pregnancy / Lactation

Pregnancy warnings:  

Pregnancy category: C

Lactation: Excreted into human milk is known in small amounts.

Pregnancy Categories:

• Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
• Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
• Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:

Suprofen is NSAID possessing the activity of analgesia, anti-inflammatory and antipyretic.

Pharmacodynamics:

Inhibition of Cyclooxygenase (COX): Suprofen prevents the formation of cyclooxygenase enzyme which is involved in the production of prostaglandins. Prostaglandins are hormones which plays an essential role in inflammation, pain and fever. As inhibitor of COX, suprofen decreases formation of prostaglandins, hence, inflammation, pain and fever.

Pharmacokinetics:

Absorption

Suprofen is absorbed by the gastrointestinal tract through oral administration.

Distribution

Suprofen is widely distributed in the body.
It has moderate binding to plasma protein.

Metabolism

Suprofen is metabolised in the liver with the major metabolic pathway involving the hepatic cytochrome P450 enzymes and especially CYP2C9 and CYP2C19 enzymes.

Excretion and Elimination

The metabolites of suprofen are removed by kidney through renal excretion. Small percentage of the drug and its metabolites may be expelled through the bile and feces. The half-life of suprofen varies but it is in the range from 1-3 hours.

Adminstartion

Administration:

Suprofen is used in tablets or capsules that are administered orally.
Do not split, chew or break the tablets unless advised by a doctor.

Patient Information Leaflet

Patient information leaflet

Generic Name: suprofen

Why do we use suprofen?

Suprofen is significant in pain relieving properties that include but are not limited to mild to moderate pain such as headaches, dental pain, dysmenorrhea and muscle pain.
It was prescribed for the treatment of inflammation as in arthritis, rheumatoid arthritis, and osteoarthritis.
Suprofen was occasionally utilized in the treatment of injuries that occurred in sports or any other physical activities owing to the fact that inflammation and pain are some of the most common characteristics of these types of injuries.
It could be taken for the management of moderate to severe pain that is anticipated for the short-term following some surgeries.