tenoxicam

Action and Spectrum

Actions and Spectrum 

tenoxicam belongs to the class of NSAIDs, which work by inhibiting enzymes called cyclooxygenases (COX-1 and COX-2). 

By inhibiting COX enzymes, tenoxicam reduces the production of prostaglandins, thereby reducing inflammation.

Drug Interaction

Adverse Reaction

Frequency defined  

1-10% 

Skin rash 

Abdominal distress  

Abdominal pain  

Constipation   

Diarrhea   

Dyspepsia   

Epigastric fullness  

Edema  

Pruritus  

Epigastric pain   

Vomiting  

Dizziness  

Headache  

Heartburn  

Nausea  

<1% 

Flushing 

Tachycardia 

Diaphoresis  

Eczema 

Hypertension  

Palpitations 

Nail disease 

Seborrhea 

Albuminuria  

Anorexia 

Skin photosensitivity 

Gastritis 

Gastrointestinal hemorrhage 

Urticaria  

Aphthous stomatitis 

Dysphagia 

Gastric hyperacidity 

Epigastric discomfort  

Esophagitis 

Glossitis 

Hematemesis  

Melena 

Stomatitis  

Xerostomia 

Cystitis  

Dysuria 

Peptic ulcer 

Reflux esophagitis 

Hematuria 

Urinary frequency 

Anemia 

Thrombocytopenia 

Abnormal liver function 

Leukopenia 

Purpuric disease 

Hepatic coma 

Angioedema 

Confusion 

Depression  

Drowsiness 

Fatigue 

Hepatic failure  

Hepatitis 

Insomnia 

Malaise 

Paresthesia 

Vertigo 

Lower limb cramp 

Nervousness 

Paresis 

Abnormal lacrimation  

Conjunctivitis 

Diplopia 

Visual disturbance 

Polyuria 

Renal function abnormality 

Bronchospasm  

Deafness  

Tinnitus  

Dyspnea 

Epistaxis 

Fever 

Post marketing report 

Erythema multiforme 

Nephrotic syndrome  

Exfoliative dermatitis 

Toxic epidermal necrolysis 

Proteinuria 

Gastrointestinal perforation 

Blurred vision 

Acute interstitial nephritis 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• tenoxicam is contraindicated in individuals who have a known hypersensitivity or allergy to drug. 

Caution: 

• tenoxicam should not be used in individuals with a history of asthma and nasal polyps. 
• tenoxicam should be avoided in individuals with active peptic ulcers or a history of gastrointestinal bleeding. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

tenoxicam reduces inflammation by decreasing the synthesis of inflammatory prostaglandins.  

By reducing the production of prostaglandins that sensitize pain receptors, tenoxicam provides pain relief. 

Pharmacodynamics 

By inhibiting prostaglandin production in the hypothalamus, which regulates body temperature, tenoxicam can reduce fever. 

Fever reduction occurs because prostaglandins are involved in the body’s thermoregulatory response to infection. 

Pharmacokinetics 

Absorption   

tenoxicam is absorbed from the gastrointestinal tract when taken orally.  

Distribution 

tenoxicam has a high volume of distribution and it distribute throughout the body’s tissues. 

Metabolism 

tenoxicam undergoes hepatic metabolism in the liver.  

Elimination and excretion 

tenoxicam is excreted through the urine. 

Adminstartion

Administration 

tenoxicam is administered orally and available in tablets and capsules form. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: tenoxicam 

Why do we use tenoxicam? 

tenoxicam is used to reduce pain and inflammation associated with rheumatoid arthritis.  

tenoxicam is used to manage pain and inflammation in osteoarthritis.  

tenoxicam can help alleviate pain and stiffness associated with ankylosing spondylitis.