Brand Name :
Fenovent, Iperol, Monburt, Fenostad, Bromifen, Berodin
Synonyms :
fenoterol, phenoterol
Class :
Beta2 Agonist
Dosage Forms & Strengths
Oral solution-0.5%
Aerosol inhalation-100mcg/actuation
Oral tablet – 2.5mg
Oral inhalation
Solution for nebulization:
Moderate symptoms
0.5 to 1.25mg every 4 hours when needed
Maximum dose-8 inhalations/day
Severe symptoms
2.5 to 5mg inhaled through nebulization of 3 doses for 20 mins maximum
Oral tablets
2.5mg thrice daily
Safety and efficacy not established
Refer adult dosing
may enhance the adverse/toxic effect of loxapine
may increase the risk or severity of hypertension when combined
may increase the risk or severity of adverse effects when combined
may increase the risk or severity of adverse effects when combined
may increase the risk or severity of adverse effects when combined
may increase the risk or severity of adverse effects when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of adverse effects when combined
may increase the risk or severity of adverse effects when combined
may increase the risk or severity of adverse effects when combined
may increase the risk or severity of adverse effects when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
Mechanism of action
It stimulates beta-2 adrenergic receptors in the lungs, causing the smooth muscles in the airways to relax and dilate. This results in increased airflow to the lungs, making breathing easier. fenoterol also reduces the release of inflammatory chemicals in the lungs, which can help to reduce airway inflammation
Spectrum
The spectrum of activity of fenoterol is similar to other beta-2 adrenergic agonists. It is most effective at treating conditions that cause airway constriction, such as asthma, bronchitis, and COPD. It can also prevent exercise-induced bronchoconstriction, temporarily narrowing the airways during or after exercise.
Frequency defined:
Headache
Nervousness
Dizziness
Shakiness
Cough
Contraindications
Caution
The following are some cautions for the use of fenoterol
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
The pharmacology of fenoterol is like other beta-2 agonists. Its effectiveness in treating respiratory conditions is due to its ability to relax the bronchial smooth muscle and improve airflow in the airways
Pharmacodynamics
The pharmacodynamics of salbutamol involve its selective activation of the beta-2 adrenergic receptors in the airway smooth muscle, leading to relaxation and dilation of the airways and improved airflow
Pharmacokinetics
Absorption
It can be administered orally or via inhalation. When given orally, it is rapidly and well absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 2-3 hours. When administered via inhalation, it is rapidly absorbed from the lungs and reaches peak plasma concentrations within a few minutes
Distribution
It is highly protein-bound, with approximately 90% of the drug bound to plasma proteins. It has a relatively large volume of distribution, which suggests that it distributes widely throughout the body
Metabolism
It is metabolized primarily in the liver via oxidation and conjugation with glucuronic acid. The major metabolites are inactive and are excreted in the urine
Elimination/Excretion
The half-life of fenoterol is approximately 3-4 hours. It is excreted primarily in the urine, with only a small amount of unchanged drug excreted in the feces
Administration
The administration of fenoterol typically involves using an inhaler or nebulizer, which allows the medication to be delivered directly to the lungs. The specific instructions for using an inhaler or nebulizer will depend on the device being used and the specific formulation of fenoterol being prescribed.
Patient information leaflet
Generic Name: fenoterol
Why do we use fenoterol?
It is a medication that belongs to the class of beta-2 adrenergic agonists, primarily used for treating respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Here are some of the common uses of fenoterol:
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