teprenone

Action and Spectrum

Actions and Spectrum: 

Action: 

Mucosal Protection: teprenone is known for its gastroprotective properties. It enhances the integrity of the gastric mucosa by stimulating the synthesis of mucosal protective factors such as prostaglandins and mucus while simultaneously reducing the production of harmful factors like reactive oxygen species (ROS) and pro-inflammatory cytokines. This action helps maintain the gastric mucosa’s structural and functional integrity, potentially preventing gastric ulcers and related complications.  

Spectrum: 

Gastric Ulcer Prevention: teprenone is often utilized to prevent gastric ulcers, particularly in individuals at risk due to factors such as nonsteroidal anti-inflammatory drug (NSAID) use or Helicobacter pylori infection. By strengthening the gastric mucosal barrier and reducing inflammation, teprenone helps mitigate the risk of ulcer formation. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Headache 

raised LFT 

constipation 

diarrhoea 

dry mouth 

anorexia 

Nausea 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication / Caution:

Allergic Reactions: Individuals with a known allergy or sensitivity to teprenone or any of the ingredients in the skincare product should avoid using it. 

Skin Sensitivity: If you have extremely sensitive or easily irritated skin, teprenone-containing products may not suit you as they may cause adverse effects. 

Pregnancy and Breastfeeding: Adequate research on the safety of teprenone during pregnancy and breastfeeding has not been conducted. Pregnant and breastfeeding individuals are typically advised to refrain from using skincare products containing teprenone Unless explicitly directed by a medical professional. 

Skin Conditions: If you have any pre-existing skin conditions, such as eczema, psoriasis, dermatitis, or open wounds on the skin, you should consult a dermatologist before using products containing teprenone, as it may exacerbate these conditions. 

Medication Interactions: If you take any prescription medications or use other topical skincare products, consult your healthcare provider or dermatologist to ensure no potential interactions between teprenone and your medications or other skincare ingredients. 

Age: While teprenone is often marketed for its anti-aging properties, not all individuals may benefit equally from it. Consult with a dermatologist to determine if it is appropriate for your skin type and age. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:

teprenone is a pharmaceutical compound with potential therapeutic applications primarily in gastroenterology. 

Pharmacodynamics:  

Heat Shock Protein (HSP) Induction: teprenone is believed to trigger the production of heat shock proteins particularly HSP70, in the gastric mucosa. These proteins help protect cells from stress and injury. 

Mucosal Defense Enhancement: It enhances the mucosal defense mechanisms in the gastrointestinal tract, including increasing mucin production, promoting blood flow, and enhancing the secretion of bicarbonate, which helps protect the gastric lining from damage by gastric acid.  

Pharmacokinetics: 

Absorption 

teprenone is absorbed in the gastrointestinal tract, but its absorption rate may vary based on the formulation. 

Distribution 

It is distributed throughout the body, with a particular affinity for the gastric mucosa. 

Metabolism 

teprenone is metabolized primarily in the liver, with some metabolites being excreted in the urine. 

Excretion and Elimination 

The exact elimination half-life and excretion pathways may vary depending on the formulation, but teprenone and its metabolites are generally eliminated via renal and fecal routes. 

Adminstartion

Administration:  

The administration is by oral route; teprenone is usually taken with meals to enhance its effectiveness and reduce the risk of gastrointestinal side effects. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: teprenone 

Why do we use teprenone?  

Gastric Ulcer Treatment: teprenone has been investigated for its potential in treating gastric ulcers and preventing their recurrence. It is believed to promote the healing of damaged gastric mucosa and reduce the risk of ulcer recurrence. 

Gastric Mucosal Protection: teprenone may have gastroprotective effects, assisting in safeguarding the stomach lining against harm triggered by a range of factors, including stress, alcohol consumption, and specific medications such as NSAIDs. 

Anti-Aging Skincare: In dermatology and skincare, teprenone has gained attention for its potential anti-aging properties.