tetrahydrozoline/zinc sulfate/hypromellose ophthalmic

Action and Spectrum

Actions and Spectrum 

tetrahydrozoline is a decongestant that reduces swelling and redness in the eyes by constricting blood vessels there. It is frequently applied to provide temporarily relieve from minor eye discomfort brought on by allergies, exhaustion or other causes. 

An astringent called zinc sulfate aids in reducing inflammation and irritation in the eye. Additionally, it has mild antiseptic qualities that could aid in infection prevention. 

A protective coating is created by the lubricant hypromellose on the surface of the eye. By keeping the eye wet and hydrated, this film assists in reducing dryness and irritation. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Transient ocular dryness 

Increased IOP 

Transient ocular burning/stinging 

Rebound conjunctival hyperemia 

Transient blurred vision 

Black Box Warning

Black Box Warning 

There are no black box warnings for the combination drug of tetrahydrozoline/zinc sulfate/hypromellose ophthalmic drug.

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• If you are now using monoamine oxidase inhibitors or have recently taken them, you should not use this drug. With MAOIs, tetrahydrozoline may cause dangerously elevated blood pressure. 
• If not prescribed by a medical professional, do not administer this drug to children under the age of six. 

Caution: 

• Use this medication only as prescribed; do not take more than that amount. 
• It is not recommended to consume this medication and it is for only topical treatment in the eyes. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: B  

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology 

tetrahydrozoline/zinc sulfate/hypromellose collectively offer a thorough method for treating eye irritation and redness.  

tetrahydrozoline has vasoconstrictor impact lessens redness and swelling and zinc sulfate and hypromellose’s astringent and lubricant characteristics aid to calm and shield the eye. 

Pharmacodynamics 

A combination medicine of tetrahydrozoline, zinc sulfate and hypromellose relieves eye redness and irritation through a variety of pharmacodynamic pathways. 

This usually begins working a few minutes after administration and lasts for several hours. The drug is typically well accepted, but some people may develop negative effects like stinging, burning or eye discomfort. 

Pharmacokinetics 

Absorption   

The drug is absorbed via the surface of the eye and into the bloodstream when it is given topically as eye drops. The formulation of the medication and the health of the eye are two variables that affect how quickly the medication is absorbed. 

Distribution 

The drug is dispersed throughout the body once it has entered the bloodstream. The solubility of the medicine and its affinity for plasma proteins are two examples of variables that affect how the drug is distributed. 

Metabolism 

There has been limited research done on the metabolism of tetrahydrozoline, zinc sulfate or the ophthalmic medication hypromellose. The medication is thought to be metabolized by liver enzymes and eliminated through the urine. 

Elimination and excretion 

The medication and its metabolites excreted in the urine. The medication’s formulation and the person’s renal function, for example, are two factors that affect the rate of excretion. 

Adminstartion

Administration:  

Eye drops are generally used to provide the ocular medication tetrahydrozoline/zinc sulfate/hypromellose. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: tetrahydrozoline/zinc sulfate/hypromellose ophthalmic 

Why do we use tetrahydrozoline/zinc sulfate/hypromellose ophthalmic? 

It is generally used to treat eye irritation and redness brought on by allergies, dryness or mild eye infections.  

This eye inflammation is brought on by an allergen like dust, pollen or pet dander. Redness, itching, burning and watery discharge are possible symptoms. 

This is a condition when the eyes don’t generate enough tears to lubricate and maintain the moisture on the surface of the eye.  

When the eyes are put through extended periods of heavy use, including when reading, using a computer or driving, this might happen. Dryness, redness and weariness may be symptoms.