zinc sulfate

Action and Spectrum

Actions and spectrum: 

Zinc is a crucial nutrient for immune function, wound healing, DNA synthesis, and growth. It is used address various deficiencies also prevent zinc deficiency in individuals with certain conditions. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Abdominal pain 

Diarrhoea 

Gastric irritation 

Headache 

Lethargy 

Vomiting 

Copper deficiency 

Dyspepsia 

Gastritis 

Irritability 

Nausea 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Zinc sulfate is contraindicated for individuals with known allergies or hypersensitivity, Wilson’s disease, hemochromatosis, pregnancy and lactation, copper deficiency, excessive zinc intake, interactions with medications, gastrointestinal disorders, renal impairment, chronic diarrhea, vegetarian or vegan diets, and alcoholism. Over intake of zinc leads to zinc toxicity and interfere with other essential minerals absorption. Zinc supplements may also interact with certain medications, gastrointestinal disorders, renal impairment, and comorbidities. 

Pregnancy / Lactation

Pregnancy consideration: pregnancy category: not assigned 

Lactation: excreted into human milk: unknown 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   

• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

Pharmacodynamics: 

Zinc has various functions like enzyme cofactor, immune function, wound healing, antioxidant activity, neurotransmitter regulation, and maintaining metal homeostasis. It involves in DNA synthesis, RNA transcription, cell division, and immune cell development. Thus can enhance immune responses and combat infections. It also aids in wound healing, regulates neurotransmitters, and maintains metal homeostasis in the gastrointestinal tract. 

Pharmacokinetics: 

Absorption 

Rapidly absorbed 

Distribution 

Widely distributed throughout the body.  

Metabolism 

Zinc undergoes minimal metabolism in the body as most of the zinc remains as free ionized form. 

Elimination and excretion 

The excretion of zinc occurs through urine and feces.  

Adminstartion

Administration: 

Dosage of zinc sulfate is determined by individual needs and purpose suggesting different dosages for different conditions. Oral administration is usually recommended with tablets or capsules swallowed with water. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: zinc sulfate 

Pronounced: (zingk sul-feyt) 

Why do we use zinc sulfate? 

Zinc sulfate is a supplement treats zinc deficiencies with insufficient dietary intake or malabsorption conditions. It supports overall health, immune function, wound healing, DNA synthesis, and growth. In dermatology it is used in topical formulations to address skin conditions and Wilson’s disease.