thiamylal

Action and Spectrum

Actions and Spectrum 

thiamylal involves enhancing the inhibitory neurotransmitter GABA (gamma-aminobutyric acid) in the brain. GABA is responsible for reducing neuronal activity and promoting relaxation and sedation.  

thiamylal enhances the effects of GABA by binding to GABA receptors, which results in decreased neuronal activity and produces a sedative, hypnotic, and anesthetic effect.

Drug Interaction

Adverse Reaction

Frequency not defined  

None 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Known hypersensitivity or allergy to thiamylal. 

Caution: 

• thiamylal should be used cautiously in patients with heart conditions or those at risk for hypotension. 
• thiamylal should be used with caution in patients with respiratory disorders. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

thiamylal can lead to cardiovascular depression, resulting in a decrease in blood pressure and heart rate. These effects need to be monitored carefully during anesthesia administration. 

Pharmacodynamics 

It enhances GABAergic neurotransmission, induces central nervous system (CNS) depression.  

thiamylal’s GABAergic effects also result in anxiolysis, which means it reduces anxiety and produces a calming effect.  

Pharmacokinetics 

Absorption   

thiamylal is directly introduced into the bloodstream and results in a rapid onset of action. 

Distribution 

thiamylal distributes throughout the body’s tissues. 

Metabolism 

thiamylal undergoes hepatic metabolism, primarily through oxidative processes in the liver.  

Elimination and excretion 

thiamylal are excreted primarily through the urine.

Adminstartion

Administration 

thiamylal is administered in the form of intravenous injection.  

Patient Information Leaflet

Patient information leaflet 

Generic Name: thiamylal 

Why do we use thiamylal? 

thiamylal is used to induce general anesthesia for surgical procedures.   

thiamylal is used in sedation and relaxation in patients before medical procedures.