From Data to Decisions: Tailoring Treatment for Pituitary Tumors
February 3, 2026
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Brand Name :
N/A
Synonyms :
thiamylal
Class :
Barbiturate, Anticonvulsant agent
Brand Name :
N/A
Synonyms :
thiamylal
Class :
Barbiturate, Anticonvulsant agent
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with Platelets inhibitors
It may enhance the risk of adverse effects when combined with Platelets inhibitors
Actions and Spectrum
thiamylal involves enhancing the inhibitory neurotransmitter GABA (gamma-aminobutyric acid) in the brain. GABA is responsible for reducing neuronal activity and promoting relaxation and sedation.
thiamylal enhances the effects of GABA by binding to GABA receptors, which results in decreased neuronal activity and produces a sedative, hypnotic, and anesthetic effect.
Frequency not defined
None
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
thiamylal can lead to cardiovascular depression, resulting in a decrease in blood pressure and heart rate. These effects need to be monitored carefully during anesthesia administration.
Pharmacodynamics
It enhances GABAergic neurotransmission, induces central nervous system (CNS) depression.
thiamylal’s GABAergic effects also result in anxiolysis, which means it reduces anxiety and produces a calming effect.
Pharmacokinetics
Absorption
thiamylal is directly introduced into the bloodstream and results in a rapid onset of action.
Distribution
thiamylal distributes throughout the body’s tissues.
Metabolism
thiamylal undergoes hepatic metabolism, primarily through oxidative processes in the liver.
Elimination and excretion
thiamylal are excreted primarily through the urine.
Administration
thiamylal is administered in the form of intravenous injection.
Patient information leaflet
Generic Name: thiamylal
Why do we use thiamylal?
thiamylal is used to induce general anesthesia for surgical procedures.
thiamylal is used in sedation and relaxation in patients before medical procedures.
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