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Brand Name :
Mixpram, Olpisone, Synaptol, Intratol, Tolkem, Tolmove
Synonyms :
tolperisone
Class :
Muscle Relaxants
Brand Name :
Mixpram, Olpisone, Synaptol, Intratol, Tolkem, Tolmove
Synonyms :
tolperisone
Class :
Muscle Relaxants
Dosage Forms & Strengths
Tablet
50 mg
Take a dose of 50 to 150 mg orally three times a day
Not determined
Refer to adult dosing
brexanolone: it may increase the risk of CNS depression with tolperisone
brimonidine: it may increase the central nervous system depressant activities of tolperisone
brivaracetam: it may increase the central nervous system depressant activities of tolperisone
bromocriptine: it may increase the central nervous system depressant activities of tolperisone
bromperidol: it may increase the central nervous system depressant activities of tolperisone
chlorprothixene: it may increase the central nervous system depressant activities of tolperisone
chlorzoxazone: it may increase the central nervous system depressant activities of tolperisone
cisapride: it may increase the central nervous system depressant activities of tolperisone
diphenhydramine: it may increase the central nervous system depressant activities of tolperisone
dolasetron: it may increase the central nervous system depressant activities of tolperisone
ethotoin: it may increase the central nervous system depressant activities of tolperisone
frovatriptan: it may increase the central nervous system depressant activities of tolperisone
Actions and Spectrum
tolperisone’s muscle relaxant properties can help reduce the intensity and frequency of these spasms, providing relief to individuals experiencing muscle pain and discomfort. This modulation helps reduce muscle contractions and spasticity, leading to muscle relaxation.
Frequency not defined
Abdominal pain
Diarrhea
Nausea
Weakness
Hypersensitivity reactions
Muscle pain
Headache
Dizziness
Tremors
Black Box Warning
None
Contraindication/Caution:
None
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
tolperisone is reduce the influx of calcium ions into muscle cells. This reduction in calcium ion levels can lead to muscle relaxation, which is particularly beneficial in conditions characterized by muscle spasms and spasticity.
Pharmacodynamics
tolperisone may have central nervous system (CNS) effects, including sedation and dizziness. These CNS effects are common side effects of the drug.
The sedative and drowsiness-inducing effects of tolperisone can be advantageous in managing conditions associated with muscle spasms.
Pharmacokinetics
Absorption
tolperisone is absorbed through the gastrointestinal tract.
Distribution
tolperisone is distributed throughout the body.
Metabolism
tolperisone undergoes metabolism in the liver through various metabolic pathways.
Elimination and excretion
tolperisone is excreted from the body through the kidneys.
Administration
tolperisone is administered orally in the form of tablets or capsules.
Patient information leaflet
Generic Name: tolperisone
Why do we use tolperisone?
tolperisone is used to relieve muscle spasms.
tolperisone can be used to manage muscle spasms and pain associated with musculoskeletal disorders.
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