Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
OJEMDA
Synonyms :
tovorafenib
Class :
BRAF kinase inhibitor
Brand Name :
OJEMDA
Synonyms :
tovorafenib
Class :
BRAF kinase inhibitor
Dosage forms and strengthsÂ
Oral suspension Â
25 mg/mlÂ
Oral tabletsÂ
100 mgÂ
Indicated for glioma
Based on BSA the recommended dose for tablet as follows
BSA:
≥ 1.40: Take 600 mg one time a week
1.13-1.39: Take 500 mg one time a week
0.90-1.12: Take 400 mg one time a week
Based on BSA the recommended dose for suspension as follows:
BSA:
≥1.40: Take 600 mg one time a week with dose volume of 24 ml
1.26-1.39: Take 525 mg one time a week with dose volume of 21 ml
1.06-1.25: Take 450 mg one time a week with dose volume of 18 ml
0.90-1.05: Take 275 mg one time a week with dose volume of 15 ml
0.84-0.89: Take 365 mg one time a week with dose volume of 14 ml
0.78-0.83: Take 300 mg one time a week with dose volume of 12 ml
0.64-0.77: Take 275 mg one time a week with dose volume of 11 ml
0.55-0.63: Take 225 mg one time a week with dose volume of 9 ml
0.49-0.54: Take 200 mg one time a week with dose volume of 8 ml
0.43-0.48: Take 175 mg one time a week with dose volume of 7 ml
0.36-0.42: Take 150 mg one time a week with dose volume of 6 ml
0.30-0.35: Take 125 mg one time a week with dose volume of 5 ml
Dosage forms and strengthsÂ
Oral suspension Â
25 mg/mlÂ
Oral tabletsÂ
100 mgÂ
tovorafenib cannot be taken with strong CYP2C8 Inhibitors
tovorafenib cannot be taken with strong CYP2C8 Inhibitors
tovorafenib cannot be taken with strong CYP2C8 Inhibitors
tovorafenib cannot be taken with strong CYP2C8 Inhibitors
tovorafenib cannot be taken with hormonal contraceptives
tovorafenib cannot be taken with hormonal contraceptives
tovorafenib cannot be taken with hormonal contraceptives
tovorafenib cannot be taken with hormonal contraceptives
tovorafenib cannot be taken with hormonal contraceptives
When corticotropin is aided by androstenediol, that promotes an increased risk of edema
When cortisone acetate is aided by androstenediol, that promotes an increased risk of edema
When desoximetasone is aided by androstenediol, that promotes an increased risk of edema
Actions and Spectrum: Â
Actions: Â
Tovorafenib treats cancer by targeting mutated BRAF protein, which accelerates cancer cell growth, halting its activity and slowing cancer progression.Â
Frequency definedÂ
≥30%Â
dry skinÂ
pyrexiaÂ
headacheÂ
vomitingÂ
viral infectionÂ
FatigueÂ
Grades 3-4Â Â
Increased creatine phosphokinase (11%)Â Â
Decreased hemoglobin (15%Â Â
Decreased phosphate (25%)Â
Black Box Warning Â
None
Contraindication/Caution: Â
ContraindicationsÂ
None Â
CautionsÂ
Embryo fetal toxicityÂ
Skin toxicity Â
HemorrhageÂ
Hepatotoxicity Â
Nf1 Associated tumorsÂ
Pregnancy & breastfeeding:Â
Pregnancy consideration:  Â
 No data is available regarding the administration of the drug during pregnancy. Â
Breastfeeding warnings:  Â
No data is available regarding the excretion of drugs in breast milk. Â
Pregnancy category: Â
Pharmacology:Â Â
Tovorafenib selectively interferes with BRAF mutated forms being active and introducing the anti-oncogenic effect to suppress tumor cells growth. Tovorafenib primarily works on blocking BRAF kinase. Â
Pharmacokinetics:Â Â
Absorption Â
The drug attains its maximum plasma levels 6.9 mcg/ml. Â
Distribution Â
The drug’s volume of distribution is 60 L/ m2.Â
Metabolism Â
Tovorafenib undergoes metabolism mainly in the liver by the enzyme CYP3A4. Â
Excretion and EliminationÂ
 Tovorafenib is excreted in urine & feces mainly at the proportion of 27% and 65% each, respectively.Â
Administration: Â
The drug is taken orally.Â
Patient information leaflet Â
Generic Name: tovorafenibÂ
Why do we use tovorafenib? Â
Tovorafenib is a drug for the treatment of a particular cancer like childhood low-grade glioma (pLGG) with a BRAF gene mutation. It is the first one with the FDA approval for this disease in terms of systemic therapy.Â
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