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Brand Name :
Trapilet, Rocornal, Travisco
Synonyms :
trapidil
Class :
Antiplatelet Agent, Vasodilator
Brand Name :
Trapilet, Rocornal, Travisco
Synonyms :
trapidil
Class :
Antiplatelet Agent, Vasodilator
Dosage Forms & Strengths
Capsule
200 mg
Tablet
200 mg
Take a daily dose of 400 to 600 mg orally in divided doses
Not determined
Refer to adult dosing
aminophenazone: it may increase the risk of bleeding with trapidil
aminosalicylic acid: it may increase the risk of bleeding with trapidil
aminophenazone: it may increase the risk of bleeding with trapidil
anagrelide: it may increase the risk of bleeding with trapidil
benoxaprofen: it may increase the risk of bleeding with trapidil
bivalirudin: it may increase the risk of bleeding with trapidil
blinatumomab: it may increase the risk of bleeding with trapidil
bortezomib: it may increase the risk of bleeding with trapidil
citalopram: it may increase the risk of bleeding with trapidil
cladribine: it may increase the risk of bleeding with trapidil
clofarabine: it may increase the risk of bleeding with trapidil
cyclophosphamide: it may increase the risk of bleeding with trapidil
Actions and Spectrum
trapidil is a vasodilator and a platelet aggregation inhibitor. It is useful in preventing the formation of blood clots within arteries and reducing the risk of thrombotic events. This vasodilatory effect reduces peripheral resistance, which can help lower blood pressure.
Frequency not defined
None
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
trapidil possesses antiplatelet properties, thus it inhibits the aggregation and activation of blood platelets. Platelets have an important role in forming blood clots, and inhibiting their activity can help prevent thrombotic events.
Pharmacodynamics
Vasodilation affects the arteries, resulting in reduced peripheral vascular resistance and decreased blood pressure.
Pharmacokinetics
Absorption
trapidil absorbed from the gastrointestinal tract after oral administration.
Distribution
trapidil is distributed throughout the body.
Metabolism
trapidil undergoes metabolism in the liver.
Elimination and excretion
trapidil is excreted from the body through renal route.
Administration
trapidil is administered orally in the form of tablets and capsules.
Patient information leaflet
Generic Name: trapidil
Why do we use trapidil?
trapidil used in the management of ischemic heart disease.
trapidil is beneficial for individuals with peripheral arterial disease.
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