Cystathionine γ-Lyase Identified as a Key Regulator of Memory and Learning
January 1, 2026
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Brand Name :
ADH, Vasostrict
Synonyms :
vasopressin
Class :
Gastrointestinal Agents; Vasopressin-Related; Antidiuretics, Hormone Analog
Brand Name :
ADH, Vasostrict
Synonyms :
vasopressin
Class :
Gastrointestinal Agents; Vasopressin-Related; Antidiuretics, Hormone Analog
Dosage forms & Strengths:
Solution for injection for dilution
20 units/ml
Ready to use solution for injection
20 units/100 ml
40 units/100 ml
60 units/100 ml
Post-Cardiotomy Shock-
0.03 units/minute intravenously initially.
Titrate up to 0.005 unit/minute at an interval of 10-15 minutes, until the required blood pressure is achieved.
Septic Shock-
0.01 units/minute intravenously initially.
Titrate up to 0.005 unit/minute at an interval of 10-15 minutes, until the required blood pressure is achieved.
Note:
It is used to raise blood pressure in patients with vasodilatory shock (such as those who have had a cardiotomy or who have sepsis) who are still hypotensive despite receiving fluids and catecholamines.
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
may have an increased hypertensive effect when combined with vasopressin
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists
It may enhance the effects when combined with urea topical by pharmacodynamic synergism
may enhance the serum concentration of CYP3A4 inhibitors
the hypertensive activity of protokylol may be increased
Actions and Spectrum:
Vasopressin also known as ADH that regulates the body water balance by increasing kidney water reabsorption, constriction of blood vessels, stimulation of smooth muscle contraction, insulin release, and oxytocin release.
Frequency Not Defined:
Black Box Warning:
It is essential to follow the dosage and administration instructions for the medication carefully.
Contraindication/Caution:
Vasopressin is contraindicated in individuals with hypertension, cerebrovascular disease, kidney disease, diabetes, and electrolyte imbalances as it constricts the blood vessels and increase blood pressure leading to risk of stroke.
Pregnancy consideration:
No proper and well-controlled studies on the drug dose are performed on pregnant females.
Breastfeeding warnings:
It is unknown if the drug is excreted in breast milk.
Pregnancy category:
Pharmacology
Vasopressin is a nonapeptide hormone that regulates physiological processes like autonomic signaling, stress response, behavior, and memory. It influences renal fluid volume, blood pressure, and stimulates the AVPR1a receptor by increasing systemic vascular resistance.
Pharmacodynamics:
Vasopressin regulates bodily fluid tonicity by releasing from pituitary gland when hypertonic conditions occur and it is reclaiming solute-free water from the kidneys for normal circulation.
Pharmacokinetics:
Pharmacokinetics studies how a drug is absorbed, distributed, metabolized, and eliminated by the body. The following parameters can describe the pharmacokinetics of vasopressin.
Absorption
When vasopressin is administered intravenously (IV), it is rapidly distributed throughout the body. It reaches peak plasma levels within minutes. It is directly injected into the bloodstream, so there is no absorption process.
When vasopressin is administered subcutaneously or intramuscularly, it is absorbed slowly. It reaches the peak plasma levels within 1-2 hours. The absorption rate in the subcutaneous and intramuscular administration routes is slower than in the previous routes.
Distribution
When vasopressin is administered intravenously, it is rapidly distributed throughout the body. It reaches peak plasma levels within minutes. It is directly injected into the bloodstream to immediately reach all the organs and tissues.
Metabolism
vasopressin is metabolized in the liver & kidney. It is then rapidly removed from the plasma.
Elimination and excretion
The half-life of vasopressin is 10-20 minutes
It is excreted as 5-10% in urine.
Administration:
The medication is administered as an intravenous solution. verapamil can be used as an additive.
The solution should be clear and colorless.
Store the premixed bottles or unopened vials under refrigeration.
Patient information leaflet
Generic Name: vasopressin
Pronounced: va-soh-preh-sn
Why do we use vasopressin?
Vasopressin is used to treat diabetes insipidus and manage stomach conditions after post-surgery or during the examination of abdominal x-rays. It enhances water reabsorption from kidneys and facilitating its return to circulation. Synthetic vasopressin is used to elevate blood pressure in adults who are experiencing severe low blood pressure due to vasodilatory shock.
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