witch hazel

Action and Spectrum

Actions and Spectrum: 

witch hazel acts as an astringent, anti-inflammatory, antimicrobial, hemostatic, and analgesic. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Liver damage  

Vomiting 

Black Box Warning

Contraindication / Caution

Contraindication/Caution: 

• Allergies 
• Medications 
• Open wounds 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

Avoid the use during pregnancy. 

Breastfeeding warnings:  

Avoid drug administration during breastfeeding. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies do not show fetal risks in the first or later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.       
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

Some of the pharmacological effects of witch hazel include: 

• Astringent: witch hazel contains high tannins, giving it astringent properties. When applied topically, it can cause the tissues to contract, which can reduce inflammation and promote healing. 
• Anti-inflammatory: witch hazel contains flavonoids, which have anti-inflammatory properties. The topical application makes it helpful in reducing redness, swelling, and irritation. 
• Antioxidant: witch hazel has antioxidant properties that help protect the skin from damage and oxidative stress caused by free radicals. 

Pharmacodynamics: 

• Hemostatic: witch hazel contains gallic acid, which has hemostatic properties and can help stop bleeding. 
• Antimicrobial: witch hazel has some antimicrobial properties; it prevents bacterial and fungal growth. 
• Analgesic: witch hazel has some analgesic properties. It relieves pain and discomfort caused by minor skin irritations. 

Pharmacokinetics: 

Absorption 

When applied topically, witch hazel is absorbed through the skin. However, the degree of absorption may vary depending on the product’s concentration and the skin’s condition. 

Distribution 

Once absorbed, the active components of witch hazel are distributed throughout the body. However, the extent of distribution is likely limited since witch hazel is primarily used topically. 

Metabolism 

The active components of witch hazel are metabolized in the liver. 

Elimination and Excretion 

There is limited information available on the elimination of witch hazel. However, the active components of witch hazel are likely eliminated from the body through urine and feces. 

Adminstartion

Administration: 

• For topical use, apply witch hazel extract, ointment, cream, or lotion to the affected area using a soft cloth or cotton ball. 
• Gently massage the product until it is fully absorbed through the skin. 
• Do not apply witch hazel to open wounds, burns, or broken skin. 
• In case of any irritation or allergic reactions, discontinue use and seek medical attention. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: witch hazel 

Pronounced: witch hey-zuh 

Why do we use witch hazel? 

• Skincare: witch hazel is commonly used topically as an astringent to help tighten and tone the skin. It also reduces inflammation, redness, and irritation caused by skin conditions such as acne, psoriasis, and eczema. 
• Hemorrhoid treatment: witch hazel is sometimes used topically to relieve itching, burning, and discomfort associated with hemorrhoids. 
• Wound healing: witch hazel has been shown to promote wound healing and reduces the risk of infection, and promote healing in minor cuts, bruises, and scrapes. 
• Eye care: witch hazel can be used topically to help reduce puffiness, redness, and inflammation around the eyes. 
• Oral care: witch hazel has mild antiseptic properties and is used as a mouthwash to help treat mouth ulcers and other oral infections. 
• Insect bites and stings: witch hazel can be used topically to help reduce itching and inflammation caused by insect bites and stings.