Alcohol Consumption Emerges as a Key Risk Factor for Buccal Cancer in India
December 24, 2025
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Brand Name :
N/A
Synonyms :
5,7-Dihydroxy-8-methoxyflavone
Class :
Herbal Analgesic,Flavanoid
Brand Name :
N/A
Synonyms :
5,7-Dihydroxy-8-methoxyflavone
Class :
Herbal Analgesic,Flavanoid
Dosage forms & Strengths
Tablet
10mg
Indicated for Inflammatory disorders:
(Off-label)
7.5 to 30mg/kg of drug was administered to the mice for anxiolytic property.
For anticonvulsant activity, according to the studies it is given to the rats intraperitoneally.
Indicated for Inflammatory disorders:
(Off-label)
7.5 to 30mg/kg of drug was administered to the mice for anxiolytic property.
For anticonvulsant activity, according to the studies it is given to the rats intraperitoneally.
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
Actions and Spectrum
Action:
Wogonin’s has shown its inhibitory effects on many cancer cell types. The p53 signaling pathway is modulated, G1 phase arrest occurs, VEGF is inhibited to prevent tumor angiogenesis, and the mitochondrial pathway triggers apoptosis.
Spectrum:
Wagonin has reported to be effective as anti-tumoral, Anti-inflammatory and neuroprotective. But there are still clinical trials being undergone.
Limited data is available
Blackbox warning
Wagonin must be avoided for therapeutic use as it is used only for research purposes. It is intended to label as “For research only” as this will help in avoiding the misuse of the drug.
Contraindications/Cautions
Hypersensitivity reactions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
Excretion of drug in breast milk is not known.
Pharmacology
Wogonin is an O-methylated flavone derived from the Chinese herb Scutellaria radix which has anti-inflammatory characteristics. In addition to suppressing inflammatory mediators like cyclooxygenase-2 and inducible nitric oxide synthase, it also prevents Peroxisome proliferator-activated receptor-gamma-mediated phosphorylation and NF-κB-P65 activation. In osteoarthritis chondrocytes, wogonin also reduces inflammation by inhibiting Interleukin-6 under IL-1β-stimulated conditions.
Pharmacodynamics
Further clinical trials must be performed to study the pharmacodynamic activity.
Pharmacokinetics
There is no much information available on the ADME
Administration
According to the study in mice, it is administered through intraperitoneally, but research is under process and the other routes of administration is not fully known.
Patient information leaflet
Generic Name: wogonin
Pronounced: woh-goh-nin
Why do we use wogonin?
Wogonin is a Chinese herbal extract used in the treatment of various cancers. It facilitates the process of cell death and suppress CDK9 expression, which in turn prevents phosphorylation of RNA polymerase II’s and thereby lowering the myeloid cell leukemia.
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