Accuracy of NHS Home Pulse Oximeters Across Skin Tones: A Diagnostic Study
January 18, 2026
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Brand Name :
Otrivin plus, Xylorex, Nazeflo-XI, Otrivine extra dual relief, Otrivin comp
Synonyms :
Xylometazoline/ipratropium
Class :
Nasal decongenstants
Brand Name :
Otrivin plus, Xylorex, Nazeflo-XI, Otrivine extra dual relief, Otrivin comp
Synonyms :
Xylometazoline/ipratropium
Class :
Nasal decongenstants
ADULT DOSING
Dosage Forms & Strengths
Nasal spray
Xylometazoline/ ipratropium
0.05% w/v/ 0.06%w/v
70µg/ 84µg
0.5mg/ml/ 0.6mg/ml
Nasal congestion
1 spray into either of the nostrils up to 3times per day with minimum gap of 6 hours
Note: total administration per day should not exceed three sprays into either of the nostril
Duration of treatment should not be more than 7 days
1 spray into either of the nostrils up to 3times per day with minimum gap of 6 hours
Note: total administration per day should not exceed three sprays into either of the nostril
Duration of treatment should not be more than 7 days
PEDIATRIC DOSING
Safety and efficacy study about the use of xylometazoline/ipratropium is not available
GERIATRIC DOSING
Refer to adult dosing
Actions and spectrum:
Ipratropium and xylometazoline. A nasal decongestant called xylometazoline works by constricting the tiny blood vessels in the nose to temporarily relieve stuffiness or congestion. Ipratropium acts as an anticholinergic,which opens up the airways by relaxing the muscles that close them. When combined, they facilitate breathing.
Frequency not defined
Atrial fibrillation
Cough
Discomfort in chest
Dysgeusia
Dysphonia
Headache
Epistaxis
Headache
Insomnia
Laryngospasm
Larygospasm
Nasal discomfort
Hypersensitivity reactions
Nasal ulceration
Palpitations
Photopsia
Rash
Mydriasis
Rhinorrhea
Tremor
Urticaria
Black Box Warning
Keep out of reach of children
Do not spray into or nearby eyes
Contraindication/Caution:
Contraindication:
Hypersensitivity
Recent nasal surgeries
Glaucoma
Children below 18 years of age
Caution:
Cystic fibrosis
Breastfeeding
Hypertension
Recurrent epistaxis
Paralytic ileus
Diabetes mellitus
Hyperthyroidism
Hypertension
Phaeochromocytoma
Pregnancy
Pregnancy consideration:
It is advised to be used with caution in pregnancy
Lactation:
Data about the excretion of xylometazoline and ipratropium into breast milk is not known.
Hence, it should be used with caution in breast feeding mothers.
Pregnancy categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the foetus `in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Xylometazoline and ipratropium is a topical nasal decongestant.
Pharmacodynamics:
Xylometazoline relieves nasal congestion by unblocking the nasal passages via decreasing swollen blood vessels.
Ipratropium helps in lowering the production of mucus.
Pharmacokinetics:
Limited data available
Administration:
Clean the nostrils
If using it for the 1st time, prime the pump four times.
If the use of spray is stopped for longer than 6 days , then repeat the same procedure as said above.
Spray the solution into each nostril up to three times per day as required
Patient information leaflet
Generic Name: xylometazoline/ipratropium
Why do we use xylometazoline/ipratropium?
Xylometazoline/ipratropium is a topical nasal decongestant. It is used to relieve stuffy or blocked nose due to hay fever, colds or allergic rhinitis.
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