zomepirac

Action and Spectrum

Actions and Spectrum: 

Actions: 

The ability of zomepirac, like other nonsteroidal anti-inflammatory medicines (NSAIDs), to block cyclooxygenase (COX) enzymes, notably COX-1 and COX-2, was fundamental to its effect. 

Spectrum: 

Zomepirac’s mechanism of action is similar to that of other nonsteroidal anti-inflammatory medicines (NSAIDs) in that it primarily works by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin synthesis. Zomepirac has the following actions: anti-inflammatory, analgesic (pain reliever), and antipyretic (fever reducer). 

Drug Interaction

Adverse Reaction

Frequency defined 

Dizziness 

Nausea 

Duodenal ulcers 

Bloody or tarry stools 

Headache 

Stomach pain 

Heart burn 

Indigestion 

Liver function abnormalities 

Skin rash 

Hypersensitivity reactions 

Thrombocytopenia 

Anemia 

Kidney damage with over use 

Black Box Warning

Black Box Warning: 

N/A 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• History of peptic ulcers 
• Severe renal impairment 
• Hepatic impairment 
• Pregnancy 
• Lactation 
• Prior history of bleeding 

Cautions 

• Increased risk of bleeding 
• Renal impairment 
• Hepatic impairment 
• Drug interactions 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

The pharmacology of zomepirac, a nonsteroidal anti-inflammatory medication (NSAID), was principally connected to its capacity to inhibit cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. 

Pharmacodynamics: 

When it was accessible and prescribed, zomepirac had pharmacodynamic qualities similar to other nonsteroidal anti-inflammatory medications (NSAIDs). Its main pharmacodynamic function was to reduce the activity of cyclooxygenase (COX) enzymes, notably COX-1 and COX-2. 

Pharmacokinetics: 

Absorption 

Zomepirac would have been absorbed from the gastrointestinal system into the bloodstream after oral dosing. The pace and amount of absorption vary between individuals and may be altered by factors such as dietary availability. 

Distribution 

Zomepirac, once in the bloodstream, would have been transported to various tissues throughout the body. NSAIDs, such as zomepirac, have a relatively large volume of distribution, implying that they can permeate tissues, particularly inflamed tissues. Metabolism 

Zomepirac would have gone through metabolic processes in the liver, although the specifics of its metabolism are unknown. Metabolites can be formed as a result of metabolism.

Elimination and Excretion 

The elimination half-life of zomepirac varies between people and may be affected by factors such as age, renal function, and liver function. In general, the elimination half-life of NSAIDs is several hours. The kidneys are the primary route of elimination for zomepirac and its metabolites. Factors such as renal function influence the rate of elimination. Some metabolites may be eliminated through the urine. 

Adminstartion

Administration: 

Typically, zomepirac tablets or capsules were taken with a full glass of water. To lessen the risk of gastrointestinal adverse effects, it is usually best to take the drug with or after a meal. This is also known as “administer with food.” Unless otherwise directed by your healthcare professional, zomepirac tablets or capsules should be swallowed whole, not crushed, chewed, or broken.

Patient Information Leaflet

Patient information leaflet 

Generic Name: zomepirac 

Pronounced: Zoh-MEP-uh-rack 

Why do we use zomepirac? 

Zomepirac was a nonsteroidal anti-inflammatory medication (NSAID) used to treat pain and inflammation in a variety of medical disorders. The primary indications for zomepirac use were Gout Management, Pain Relief, Anti-Inflammatory Action, and Fever Reduction.